Scopus
YÖKSİS Eşleşti
High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin
Brain Research Bulletin · Aralık 2020
YÖKSİS Kayıtları
High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin
Brain Research Bulletin · 2020 SCI-Expanded
PROFESÖR NİLSEL OKUDAN →
High dose simvastatin and rosuvastatin impair cognitive abilities of healthy rats via decreasing hippocampal neurotrophins and irisin
Brain Research Bulletin · 2020 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiBrain Research Bulletin
Yayın TarihiAralık 2020
Cilt / Sayfa165 · 81-89
Scopus ID2-s2.0-85091938357
Özet
Background: Statins are cholesterol lowering drugs that decrease the risk of cardiovascular events, but they are related with a few unfavorable symptoms in skeletal muscle including myopathy, and mild to moderate fatigue. Additionally, there has been discrepancies about the impacts of statins on brain and cognition. This study aimed to examine the impacts of two different statins, lipophilic simvastatin and hydrophilic rosuvastatin on cognitive functions in normal healthy rats. Simultaneously, we investigated the alterations of neurotropins and irisin levels in hippocampus and myokine levels in skeletal muscle. Methods: The rats were dosed with 88 mg kg body weight−1 day−1 simvastatin (n = 8), 150 mg kg body weight−1 day−1 rosuvastatin (n = 8) or vehicle (n = 8) for 18 days via oral gavage. After that behavioral assessment was performed and hippocampus and skeletal muscle samples were taken for the analysis of neurotrophins and irisin levels. Results: Locomotion and learning and memory functions were lower, but anxiety levels were higher in the simvastatin and rosuvastatin groups than in the control group (P < 0.05). Hippocampal neurotrophins and irisin levels were lower, but skeletal muscle brain-derived neurotrophic factor (BDNF) and irisin levels were higher in the simvastatin and rosuvastatin groups than in the control group (P < 0.05). Conclusion: These findings suggest that high dose simvastatin and rosuvastatin impair cognitive functions via decreasing BDNF, NGF and irisin levels in the hippocampus.
Yazarlar (2)
1
Nilsel Okudan
2
Muaz Belviranli
Anahtar Kelimeler
Anxiety
Cognition
Irisin
Neurotrophins
Rosuvastatin
Simvastatin
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
11
Atıf
2
Yazar
6
Anahtar Kelime