Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Early assessment of extremity compartment syndrome by biochemical markers in a rat model
Turkish Journal of Medical Sciences · Ocak 2023
YÖKSİS Kayıtları
Early assessment of extremity compartment syndrome by biochemical markers in a rat model
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2023 SCI-Expanded
PROFESÖR İBRAHİM ÖZKAN ÖNAL →
Early assessment of extremity compartment syndrome by biochemical markers in a rat model
The Scientific and Technological Research Council of Turkey (TUBITAK-ULAKBIM) - DIGITAL COMMONS JOURNALS · 2023 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Early assessment of extremity compartment syndrome by biochemical markers in a rat model
TURKISH JOURNAL OF MEDICAL SCIENCES · 2023 SCI-Expanded
PROFESÖR HÜSAMETTİN VATANSEV →
Makale Bilgileri
DergiTurkish Journal of Medical Sciences
Yayın TarihiOcak 2023
Cilt / Sayfa53 · 1-9
Scopus ID2-s2.0-85149132544
Erişim🔓 Açık Erişim
Özet
Background/aim: This experimental study aimed to define a biochemical marker that will enable early diagnosis of acute compartment syndrome (ACS) of extremities, a mortal condition that occurs due to trauma. Materials and methods: A total of 15 Wistar rats were included in the study in which saline infusion technique, a clinically compatible ACS model, was applied. After the rats were anesthetized with ketamine-xylazine, the in-compartment pressure of the hind limb was slowly increased with saline delivered through the angiocatheter, and after reaching the target compartment pressure, the pressure level was kept with a rubber tourniquet. The in-compartment pressure level was continuously monitored with a pressure transducer. The rats were divided into three groups. No intervention was applied to the control group (CG) (n = 3). In study group 1 (SG1) (n = 6), ACS was created using the saline infusion technique, keeping the in-compartment pressure between 30 and 40 mmHg for 45 min. In study group 2 (SG2) (n = 6), ACS was created using the saline infusion technique, keeping the in-compartment pressure between 30 and 40 mmHg for 90 min. Fasciotomy was performed on all rats. Tissue samples were obtained for histopathological examination and blood samples for biochemical analysis. Results: Total oxidant status (TOS) (p = 0.004), ischemia-modified albumin (IMA) (p = 0.030), aspartate transferase (AST) (p = 0.003) and neopterin (p = 0.012) levels differed significantly between groups in the early period of muscle ischemia. In fact, TOS levels differed significantly between the groups even in the cellular phase where signs of ischemia were not observed (p = 0.048, p = 0.024). According to histopathological evaluation, there was no significant difference between the groups. Conclusion: TOS can be detected in the early reversible stage of ischemia, when the histopathological findings of ACS do not occur.
Yazarlar (5)
1
Ahmet Yıldırım
2
Ozkan Onal
ORCID: 0000-0002-5574-1901
3
Zeliha Esin Celik
4
Hüsamettin Vatansev
5
Esra Paydas Hataysal
ORCID: 0000-0002-3538-8135
Anahtar Kelimeler
biochemical markers
Compartment syndrome
diagnostic techniques
ischemia
neopterin
trauma
Kurumlar
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul Turkey
Medova Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
1
Atıf
5
Yazar
6
Anahtar Kelime