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Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats

Medycyna Weterynaryjna · Ocak 2022

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YÖKSİS Kayıtları
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
Medycyna Weterynaryjna - Redakcja · 2023 SCI-Expanded
Dr. Öğr. Üyesi MUSTAFA BODU →
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
Medycyna Weterynaryjna · 2022 SCI-Expanded
Doç. Dr. DURMUŞ HATİPOĞLU →
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
Medycyna Weterynaryjna - Redakcja · 2023 SCI-Expanded
Doç. Dr. MEHMET BURAK ATEŞ →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 13 kaydı bulundu.

YÖKSİS Kayıtları — ISSN Eşleşmesi
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Effect of the tumbling process and kappa-carrageenan usage on the quality characteristics of meat loaf
2020 ISSN: 0025-8628 SCI-Expanded Q4
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Effect of the Tumbling Process and Kappa-Carrageenan Usage on the Quality Characteristics of Meat Loaf
2020 ISSN: 0025-8628 SCI-Expanded Q4
Doç. Dr. MUHAMMET ALİ CEBİRBAY →
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
2023 ISSN: 0025-8628 SCI-Expanded Q4
Doç. Dr. MEHMET BURAK ATEŞ →
Concentrations of some elements in blood serum of Angora goats
2006 ISSN: 0025-8628 SCI-Expanded
Prof. Dr. ENVER YAZAR →
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
2023 ISSN: 0025-8628 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSTAFA BODU →
Protective effects of Nigella sativa oil against bisphenol A-induced testicular toxicity in rats
2022 ISSN: 0025-8628 SCI-Expanded Q4
Doç. Dr. DURMUŞ HATİPOĞLU →
Concentrations of some elements in blood serum of Angora goats
2006 ISSN: 0025-8628 SCI 1 atıf
Prof. Dr. VAHDETTİN ALTUNOK →

Makale Bilgileri

Dergi Medycyna Weterynaryjna
ISSN00258628
Yayın TarihiOcak 2022
Cilt / Sayfa77
DOI10.21521/MW.6719
Scopus ID2-s2.0-85143159861
Erişim🔓 Açık Erişim
Özet The study investigated the protective effect of Nigella sativa (NS) oil against testicular damage induced by bisphenol A (BPA). A total of 36 Wistar Albino rats were divided into 4 groups: control (1 ml olive oil), NS (5 ml/kg NS), BPA (100 mg/kg BPA in 1 ml olive oil), BPA+NS (100 mg/kg BPA + 5 ml/kg NS). During the 30-day experiment, all substances were administered by oral gavage. The levels of testosterone and LH in serum, as well as MDA, GSH, SOD, TNF-α, IL-6 and IL-10 levels in testicular tissue were measured by ELISA. Spermatological examinations and histopathological analyses of testicular tissue were also performed. BPA was found to raise LH while reducing the serum testosterone level. BPA caused a decrease in GSH, SOD, TNF-α and IL-6, but an increase in MDA and IL-10. BPA also reduced sperm motility, plasma membrane integrity, mitochondrial activity and acrosome membrane integrity. Oedema, hyperaemia, mononuclear cell infiltration in the interstitial tissue, as well as giant cell formations, degeneration and necrosis in the seminiferous tubules were seen in the BPA group. In addition, reductions in germinative epithelium, tubule diameter and the Johnson testicular score were noted. In rats receiving NS, hormonal profile, oxidative stress markers and cytokine levels were within normal limits. NS improved sperm motility, mitochondrial activity (JC1), plasma membrane integrity (SYBR-14) and partially acrosome membrane integrity (FITC-PNA). NS reduced testis inflammation, significantly ameliorated the testicular score and, to a lesser extent, increased germinative epithelium thickness and tubule diameter. It was concluded that NS has a protective effect against BPA-induced testicular toxicity.

Yazarlar (3)

1
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
2
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
3
Mustafa Bodu
ORCID: 0000-0002-8432-7347

Anahtar Kelimeler

antioxidant BPA histopathology Nigella sativa testis

Kurumlar

Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Medycyna Weterynaryjna
Q3
SJR Skoru0,185
H-Index25
YayıncıPolskie Towarzystwo Nauk Weterynaryjnych
ÜlkePoland
Veterinary (miscellaneous) (Q3)
Dergi sayfasına git

Metrikler

1
Atıf
3
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

MB
MUSTAFA BODU
Dr. Öğr. Üyesi

Hızlı Erişim

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