Scopus
YÖKSİS Eşleşti
Acrylamide-treatment and responses to phenylephrine and potassium in rat aorta
Acta Physiologica Hungarica · Aralık 2012
YÖKSİS Kayıtları
Acrylamide treatment and responses to phenylephrine and potassium in rat aorta
Acta Physiologica Hungarica · 2012 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Acrylamide treatment and responses to phenylephrine and potassium in rataorta
ACTA PHYSIOLOGICA HUNGARICA · 2012 SSCI
PROFESÖR NİLSEL OKUDAN →
Makale Bilgileri
DergiActa Physiologica Hungarica
Yayın TarihiAralık 2012
Cilt / Sayfa99 · 420-429
Scopus ID2-s2.0-84871301082
Özet
Acrylamide (ACR) is a chemical used in many industries around the world and was found to form naturally in foods cooked at high temperatures. The aim of the present study is to evaluate the influence of ACR treatment on vascular responses to phenylephrine (PHE; 10-9-3×10-4 M) and potassium chloride (KCl; 5-100 mM). We also examined the role of gender in these responses. The animals in both genders were divided into three groups as follows. (1) Control animals, (2) ACR-I; ACR-treated (2 mg/kg-d for 90 days), (3) ACR-II; ACR-treated (5 mg/kg-d for 90 days). Male rat aortas were more sensitive to PHE and KCl than female aortas. ACR-treatment increased the sensitivity to PHE and KCl, in both genders. Compared to the control group, ACR treatment significantly reduced the luminal area of both male and female rat aortas. Furthermore, the responses to PHE and KCl were similar in both 2 mg/kg-d ACR-treated rat aortas with 5 mg/kg-d ACR-treated rat aortas, in both genders. The results of this study suggest that ACR treatment affects vascular contractility and morphology in both gender of rat aorta. © 2012 Akadémiai Kiadó, Budapest.
Yazarlar (6)
1
E. Esra Nurullahoǧlu-Atalik
2
Nilsel Okudan
3
Muaz Belviranli
4
Hasan Esen
5
Y. Yener
6
Yasemin Öznurlu
Anahtar Kelimeler
acrylamide
aorta
contractions
gender
KCl
phenylephrine
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
NEÜ Meram Medicine Faculty
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Konya
Konya Turkey
Metrikler
3
Atıf
6
Yazar
6
Anahtar Kelime