Scopus
YÖKSİS Eşleşti
Synthesis of new water-soluble phosphonate calixazacrowns and their use as drug solubilizing agents
Journal of Inclusion Phenomena and Macrocyclic Chemistry · Aralık 2012
YÖKSİS Kayıtları
Synthesis of new water soluble phosphonate calixazacrowns and their use as drug solubilizing agents
Journal of Inclusion Phenomena and Macrocyclic Chemistry · 2012 SCI-Expanded 5 atıf
PROFESÖR ŞEREF ERTUL →
Makale Bilgileri
DergiJournal of Inclusion Phenomena and Macrocyclic Chemistry
Yayın TarihiAralık 2012
Cilt / Sayfa74 · 293-303
Scopus ID2-s2.0-84864443175
Özet
This study presents the selective chloromethylation of calix[4](aza)crown ethers 2a-c, using chloromethyl n-octyl ether and SnCl 4 in chloroform at room temperature in good yield for the first time. Chloromethylated products 2a-c are used as key intermediates to synthesize new water-soluble p-phosphonato calix[4](aza)crown ethers 5a-c. Liquid-liquid phase extraction and phase solubility studies with poor water soluble drug molecules such as nifedipine, niclosamide and furosemide are performed to evaluate their binding properties. Among the studied drugs, furosemide was the most effectively dissolved drug by p-phosphonato calix[4](aza)crown ethers 5a-c in water. © 2012 Springer Science+Business Media B.V.
Yazarlar (3)
1
Mevlut Bayrakci
2
Seref Ertul
3
Mustafa Yilmaz
Anahtar Kelimeler
Calixarene
Chloromethylation
Furosemide
Niclosamide
Nifedipine
Kurumlar
Niğde Ömer Halisdemir University
Nigde Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
16
Atıf
3
Yazar
5
Anahtar Kelime