Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Nerium oleander distillate improves fat and glucose metabolism in high-fat diet-fed streptozotocin-induced diabetic rats
International Journal of Endocrinology · Aralık 2012
YÖKSİS Kayıtları
Nerium oleander Distillate Improves Fat and Glucose Metabolism in High Fat Diet Fed Streptozotocin Induced Diabetic Rats
International Journal of Endocrinology · 2012 SCI-Expanded 10 atıf
PROFESÖR KAMİL ÜNEY →
Nerium oleander Distillate Improves Fat and Glucose Metabolism in High Fat Diet Fed Streptozotocin Induced Diabetic Rats
International Journal of Endocrinology · 2012 SCI-Expanded 10 atıf
PROFESÖR AHMET LEVENT BAŞ →
Nerium oleander Distillate Improves Fat and Glucose Metabolism in High Fat Diet Fed Streptozotocin Induced Diabetic Rats
International Journal of Endocrinology · 2012 SCI-Expanded
PROFESÖR AHMET LEVENT BAŞ →
Makale Bilgileri
DergiInternational Journal of Endocrinology
Yayın TarihiAralık 2012
Cilt / Sayfa2012
Scopus ID2-s2.0-84871380149
Erişim🔓 Açık Erişim
Özet
Diabetes was induced by intraperitoneal injection of streptozotocin (35 mg/kg bw) in all rats of five groups after being fed for 2 weeks high-fat diet. Type 2 diabetic Nerium-oleander- (NO-) administered groups received the NO distillate at a dose of 3.75, 37.5, and 375 g/0.5 mL of distilled water (NO-0.1, NO-1, NO-10, resp.); positive control group had 0.6 mg glibenclamide/kg bw/d by gavage daily for 12 weeks. Type 2 diabetic negative control group had no treatment. NO distillate administration reduced fasting blood glucose, HbA1c, insulin resistance, total cholesterol, low density lipoprotein, atherogenic index, triglyceride-HDL ratio, insulin, and leptin levels. Improved beta cell function and HDL concentration were observed by NO usage. HDL percentage in total cholesterol of all NO groups was similar to healthy control. NO-10 distillate enhanced mRNA expressions of peroxisome proliferator-activated- receptor- (PPAR-) α, β, and γ in adipose tissue and PPAR-α-γ in liver. The findings from both in vivo and in vitro studies suggest that the considerable beneficial effect of NO distillate administration at a dose of 375 g/0.5 mL of distilled water may offer new approaches to treatment strategies that target both fat and glucose metabolism in type 2 diabetes. © 2012 Ahmet Levent Bas et al.
Yazarlar (5)
1
A. L. Baş
2
Sule Demirci
3
Nuray Yazihan
ORCID: 0000-0003-1237-8468
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
Ezgi Ermis Kaya
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
27
Atıf
5
Yazar