Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Increased glucose uptake and insulin binding activity of Nerium Oleander in hepatocytes and adipocytes
Kafkas Universitesi Veteriner Fakultesi Dergisi · Ocak 2013
YÖKSİS Kayıtları
Increased Glucose Uptake and Insulin Binding Activity of Nerium Oleander in Hepatocytes and Adipocytes
Kafkas Universitesi Veteriner Fakultesi Dergisi · 2013 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI-Expanded
Doç. Dr. ÖZCAN ŞAHİN →
Evaluation of 305-Day Lactation Milk Yield Predictions from Pre-Peak Partial Milk Yields Using Some Data Mining Algorithms
2026 ISSN: 1300-6045 SCI Q3
Doç. Dr. ÖZCAN ŞAHİN →
Hayvan Koruma Kavramı ve Biyoetik Çerçevesinde Yaban Hayatı Koruma ve Yaban Hayatı Geliştirme Sahaları
2012 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Anatomy of the Cervical Canal in the Angora Goat Capra hircus
2010 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. KAMİL BEŞOLUK →
Bir Ceylanda Gazella gazella Generalize Reaktif Amiloidoz Olgusu
2013 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Prevalence of Bartonella henselae in Pet and Stray Cats from the Aspect of Public Health: A Research Sample in the Concept of One Medicine - One Health
2015 ISSN: 1300-6045 SCI-Expanded Q3
Prof. Dr. MEHMET MADEN →
Fatty Acid Composition and Conjugated Linoleic Acid CLA Content of Some Commercial Milk in Turkey
2010 ISSN: 1300-6045 SCI-Expanded 5 atıf
Prof. Dr. GÖKHAN ZENGİN →
The potential of microarray databases to identify tissue specific genes
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. HİLAL ARIKOĞLU →
An Application of Bootstrap Technique in Animal Science EggYolk Color Sample
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ALİ AYGÜN →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. RAMAZAN ÇÖL →
The Effect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded Q4
Doç. Dr. ARİFE EZGİ TELLİ →
Türkiye’de Deney Hayvanı Kullanmaya Yetkili Kişilerin Hayvan Kullanımına Yönelik Tutumları
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. GÖKHAN ASLIM →
Evaluation of Acute Phase Proteins Some Cytokines and Hemostatic Parameters in Dogs with Sepsis
2015 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. HASAN GÜZELBEKTEŞ →
TheEffect of Eugenol on Survival of Listeria monocytogenes Inoculated İnegöl Meatball
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. ÜMİT GÜRBÜZ →
Structural and Functional Properties of the Distal Muscles ofFront and Hind Legs of Malakan Horses (Equus caballus)
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA ORHUN DAYAN →
A Comparison of Different Analysis Methods for Milk Urea Nitrogen
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. MUSTAFA SELÇUK ALATAŞ →
Effects of Dietary Inactive Yeast and Live Yeast on Performance Egg Quality Traits Some Blood Parameters and Antibody Production to SRBC of Laying Hens
2015 ISSN: 1300-6045 SCI-Expanded
Prof. Dr. SUZAN YALÇIN →
İç Anadolu Bölgesi Konya Bölümü Folklorunda Ruminantların Paraziter Hastalıkları ve Tedavi Yöntemleri
2015 ISSN: 1300-6045 SSCI
Prof. Dr. AŞKIN YAŞAR →
Etanersept endotoksemi tedavisinde kullanılabilir mi
2013 ISSN: 1300-6045 SCI-Expanded 2 atıf
Prof. Dr. KAMİL ÜNEY →
Makale Bilgileri
ISSN13006045
Yayın TarihiOcak 2013
Cilt / Sayfa19 · 25-30
Scopus ID2-s2.0-84870863423
Özet
Type 2 diabetes mellitus (DM) affects a large population worldwide. DM is often considered as a syndrome of disordered glucose metabolism. Current conventional drug therapies for DM are usually insufficient and medicinal herbs with antihyperglycemic activities are increasingly sought by diabetic patients and health care professionals. Nerium Oleander (N.O.) is known to be effective in lowering of postprandial blood glucose in DM patients as a folk remedy. In this study we aimed to evaluate effect of N.O. distillate in glucose uptake activity of hepatocytes and adipocytes. The human hepatoma cells Hep3B and mouse adipocyte 3T3-L1 cells were cultured. Depending on the groups, different concentrations insulin (1, 10, 20 IU/ml) and N.O. (0.1, 1, 10, 50 μg/ml) were added to medium for 48 h. Cellular toxicity and proliferation were evaluated by LDH secretion levels and MTT test. A metabolizable fluorescent derivative of glucose, 2-NBDG and FITC-insulin were used for glucose uptake and insulin binding activity. Insulin increased cellular proliferation and decreased LDH leakage and apoptosis in both cell types. Lower dosages of N.O. has no significant effect on apoptosis and cell number while at the highest dosages minimal cytotoxicity was seen mainly in adipocytes. Main effect of N.O. treatment was increased glucose uptake in Hep3B and 3T3-L1 cells (P<0.001). Our results showed that N.O. may be offered as new approaches to treatment of type 2 diabetes by modulating cellular glucose uptake.
Yazarlar (5)
1
Nuray Yazihan
ORCID: 0000-0003-1237-8468
2
A. L. Baş
3
Ezgi Ermis
4
Sule Demirci
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Adipocytes
Glucose uptake
Hepatocytes
Insulin binding
Nerium oleander
Type II diabetes mellitus
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Kafkas Universitesi Veteriner Fakultesi Dergisi
Q3
OA
SJR Skoru0,261
H-Index29
YayıncıKafkas University
ÜlkeTurkey
Veterinary (miscellaneous) (Q3)
Metrikler
6
Atıf
5
Yazar
6
Anahtar Kelime