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Scopus YÖKSİS DOI Eşleşti SJR Q2

Bioavailability and pharmacokinetic profile of levofloxacin following intravenous, intramuscular and oral administration in turkeys

British Poultry Science · Ocak 2014

YÖKSİS Kayıtları

Bioavailability and pharmacokinetic profile of levofloxacin following intravenous intramuscular and oral administration in turkeys

British Poultry Science · 2014 SCI-Expanded

Prof. Dr. KAMİL ÜNEY →

Bioavailability and pharmacokinetic profile of levofloxacin following intravenous intramuscular and oral administration in turkeys

British Poultry Science · 2014 SCI-Expanded

Prof. Dr. MUAMMER ELMAS →

YÖKSİS Kayıtları — ISSN Eşleşmesi

The effect of dietary calcium concentration and particle size on performance eggshell quality bone mechanical properties and tibia mineral contents in moulted laying hens

2011 ISSN: 0007-1668 SCI

Prof. Dr. ALPÖNDER YILDIZ →

10.1080/00071668.2011.641502

Embryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999

2000 ISSN: 0007-1668 SSCI 25 atıf

Prof. Dr. HASAN HÜSEYİN DÖNMEZ →

Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers

2000 ISSN: 0007-1668 SSCI 31 atıf

Prof. Dr. HASAN HÜSEYİN DÖNMEZ →

Embryotoxicity assay of aflatoxin produced by Aspergillusparasiticus NRRL 2999

2000 ISSN: 0007-1668 SSCI

Prof. Dr. EMRAH SUR →

10.1080/713654961

Effects of aflatoxin B1 on the development of the bursaof Fabricius and blood lymphocyte acid phosphatase ofthe chicken

2003 ISSN: 0007-1668 SSCI

Prof. Dr. EMRAH SUR →

10.1080/00071660310001618352

Effects of continuous supplementations of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens

2000 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. BÜNYAMİN TRAŞ →

10.1080/00071660020009225

Effects of dietary boron supplementation on some biochemical parameters peripheral blood lymphocytes splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol vitamin D content

2005 ISSN: 0007-1668 SCI

Prof. Dr. FİRUZE KURTOĞLU →

10.1080/00071660400024001

Embryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999 title

2000 ISSN: 0007-1668 SSCI

Prof. Dr. İLHAMİ ÇELİK →

10.1080/713654961

Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers

2000 ISSN: 0007-1668 SSCI

Prof. Dr. İLHAMİ ÇELİK →

10.1080/713654954

Bioavailability and pharmacokinetic profile of levofloxacin following intravenous intramuscular and oral administration in turkeys

2014 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. KAMİL ÜNEY →

10.1080/00071668.2013.860214

Effects of polyvinylpolypyrrolidone synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis

1998 ISSN: 0007-1668 SCI 134 atıf

Prof. Dr. TUFAN KEÇECİ →

10.1080/00071669889051

2005 ISSN: 0007-1668 SCI 55 atıf

Prof. Dr. TUFAN KEÇECİ →

10.1080/00071660400024001

Evaluation of the detoxifying effect of yeast glucomannan on aflatoxicosis in broilers as assessed by gross examination and histopathology

2005 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. HALİS UĞUZ →

10.1080/00071660500124487

The effects of withdrawal of vitamin and trace mineral supplements from layer diets on egg yield and trace mineral composition

2001 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. NURETTİN GÜLŞEN →

Effects of continuous supplementations of ascorbic acid aspirin vitamin E and selenium on some haematological parameters and serumsuperoxide dismutase level in broiler chickens

2000 ISSN: 0007-1668 SCI-Expanded 24 atıf

Prof. Dr. MUAMMER ELMAS →

The effects of different dietary copper on production performance and cholesterol concentrations of egg in laying hens

2004 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. TAHİR BALEVİ →

Effects of Echinacea extract on the performance antibody titres andintestinal histology of layer chicks

2010 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. TAHİR BALEVİ →

Effect of clinoptilolite on performance of broiler chickens during experimental aflatoxicosis

2000 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. HALİS UĞUZ →

Emryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999

2000 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. HALİS UĞUZ →

Effects of polyvinyl polypyrrolidone synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis

1998 ISSN: 0007-1668 SCI-Expanded

Prof. Dr. HALİS UĞUZ →

Makale Bilgileri

Dergi British Poultry Science

ISSN00071668

Yayın TarihiOcak 2014

Cilt / Sayfa55 · 115-119

DOI10.1080/00071668.2013.860214

Scopus ID2-s2.0-84898976104

Özet 1. The pharmacokinetics and bioavailability of levofloxacin in turkeys were investigated after a single intravenous (IV), intramuscular (IM) and oral (PO) administration of 10 mg/kg body weight.2. The concentrations of levofloxacin in plasma samples were assayed using a microbiological assay method and pharmacokinetic parameters were calculated by non-compartmental analysis.3. Following IV administration, the elimination half-life (t0.5(β)), volume of distribution at steady state (Vdss) and total body clearance (Cl) were 4.49 h, 1.31 l/kg and 0.23 l/h/kg, respectively.4. After single IM and PO administrations at the same dose, levofloxacin was rapidly absorbed as indicated by an absorption half-life (t0.5ab) of 1.02 and 0.76 h, respectively; maximum plasma concentrations (Cmax) of 5.59 and 5.15 μg/ml were obtained at a maximum time (Tmax) of 2 h for both routes and levofloxacin bioavailability (F) was 96.5 h and 79.9% respectively after IM and PO administration. In vitro plasma protein binding of levofloxacin was 24.3%.5. Based on these pharmacokinetic parameters, a dose of 10 mg/kg body weight given intramuscularly or orally every 24 h in turkeys can maintain effective plasma concentrations with bacterial infections with (minimum inhibitory concentration) MIC90 > 0.1 μg/ml. © 2014 British Poultry Science Ltd.