Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q1
Implications from a pharmacogenomic analysis: Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · Ocak 2014
YÖKSİS Kayıtları
Implications from a pharmacogenomic analysis: iNerium oleander/i leaf distillate supplemented diet regulates cholesterol metabolism in rats/title
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. YAVUZ BAĞCI →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. YAVUZ BAĞCI →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. YAVUZ BAĞCI →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. YAVUZ BAĞCI →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Implications from a pharmacogenomic analysis: iNerium oleander/i leaf distillate supplemented diet regulates cholesterol metabolism in rats/title
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
Pharmaceutical Biology · 2014 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
2014 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. YAVUZ BAĞCI →
Epilobium hirsutum alters xenobiotic metabolizing CYP1A1 CYP2E1 NQO1 and GPx activities mRNA and protein levels in rats
2013 ISSN: 1388-0209 SCI-Expanded 3 atıf
Prof. Dr. SERDAR KARAKURT →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
2014 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Biological activities and DNA interactions of Amanita ovoidea
2015 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. HASAN HÜSEYİN DOĞAN →
Implications from a pharmacogenomic analysis Nerium oleander leaf distillate supplemented diet regulates cholesterol metabolism in rats
2014 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Biological activities and DNA interactions of Amanita ovoidea
2015 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. EMİNE ARSLAN →
Biological activity and fatty acid composition of Caesar s mushroom
2013 ISSN: 1388-0209 SCI-Expanded 2 atıf
Prof. Dr. HASAN HÜSEYİN DOĞAN →
Antimicrobial activities of some mushrooms in Turkey
2013 ISSN: 1388-0209 SCI-Expanded 1 atıf
Prof. Dr. HASAN HÜSEYİN DOĞAN →
Implications from a pharmacogenomic analysis: iNerium oleander/i leaf distillate supplemented diet regulates cholesterol metabolism in rats/title
2014 ISSN: 1388-0209 SCI-Expanded
Prof. Dr. AHMET LEVENT BAŞ →
Antimicrobial Activities of Some Plants from the Eastern Anatolia Region of Turkey
2005 ISSN: 1388-0209 SCI
Prof. Dr. MEHMET TUZCU →
Isoquinoline alkaloids isolated from Glaucium corniculatum var. corniculatum and Glaucium grandiflorum subsp. Refractum var. torquatum with bioactivity studies
2023 ISSN: 1388-0209 SCI-Expanded Q1
Prof. Dr. OSMAN TUGAY →
Makale Bilgileri
Dergi
Pharmaceutical Biology
ISSN13880209
Yayın TarihiOcak 2014
Cilt / Sayfa52 · 988-993
Scopus ID2-s2.0-84904286000
Erişim🔓 Açık Erişim
Özet
Context: Despite the usage of Nerium oleander L. (Apocynaceae) for anticancer studies and traditional remediation, the regulatory effect of N. oleander leaf distillate on cholesterol metabolism is not disclosed sufficiently. Objective: Cholesterol is an important biological molecule and the synthesis rate is regulated by the amount of cholesterol uptake from the diet. The aim of this study was to investigate the regulation of cholesterol metabolism in response to a high-fat diet (HFD) and the effects of N. oleander leaf distillate-supplemented diet (NOHFD) in rats. Materials and methods: Microarray technology was used to clarify the regulation of cholesterol mechanism in HFD and NOHFD-fed rats (375μg/0.5mL distilled water applied by gavage). The treatment period was 90 days. Rat liver tissues were used for microarray analysis using the Affymetrix GeneChip Rat Genome platform. Results of groups were statistically analyzed with the Partek 6.6 bioinformatic program. Results: The HFD group exhibited alterations in the expression levels of about 1945 genes with respect to the normal diet (ND) group. The results showed that expression levels of 47 genes were altered related to cholesterol metabolism in HFD and NOHFD groups. The expression levels of seven genes in the NOHFD group were significantly closer to those in the ND group than those of the HFD group. Discussion and conclusion: To conclude, findings suggest that N. oleander leaf distillate-supplemented food has considerable beneficial effects on cholesterol metabolism-related gene expression levels. © 2014 Informa Healthcare USA, Inc.
Yazarlar (6)
1
Meltem Demirel Kars
2
Burcu Asena Odabaşi
3
Gökhan Kars
ORCID: 0000-0002-2507-2305
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
Yavuz Bağci
6
A. L. Baş
Anahtar Kelimeler
High fat diet
Liver
Microarray
Phytotherapy
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Pharmaceutical Biology
Q1
OA
SJR Skoru1,121
H-Index103
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Complementary and Alternative Medicine (Q1)
Drug Discovery (Q1)
Medicine (miscellaneous) (Q1)
Pharmaceutical Science (Q1)
Pharmacology (Q1)
Molecular Medicine (Q2)
Metrikler
4
Atıf
6
Yazar
4
Anahtar Kelime