Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal · Ocak 2015
YÖKSİS Kayıtları
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2015 SCI-Expanded 1 atıf
PROFESÖR KAMİL ÜNEY →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2015 SCI-Expanded 1 atıf
PROFESÖR KAMİL ÜNEY →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2015 SCI-Expanded 1 atıf
PROFESÖR AHMET LEVENT BAŞ →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal · 2015 SCI-Expanded
PROFESÖR AHMET LEVENT BAŞ →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal · 2015 SCI-Expanded
PROFESÖR AHMET LEVENT BAŞ →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal · 2015 SCI-Expanded
PROFESÖR AHMET LEVENT BAŞ →
Protective effect of distillated Nerium oleander on heart of type 2 diabetic rats
Bratislava Medical Journal · 2015 SCI-Expanded
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiBratislava Medical Journal
Yayın TarihiOcak 2015
Cilt / Sayfa116 · 451-456
Scopus ID2-s2.0-84939199462
Erişim🔓 Açık Erişim
Özet
OBJECTIVES: The current study aims to investigate the possible role of NO distillate either for therapeutic or for protective potential in diabetic cardiomyopathy. BACKGROUND: Protective and restorative effects of distillated Nerium oleander (NO) on the diabetes-induced electrophysiological and structural alterations were investigated. METHODS: Type 2 diabetes was induced by combination of single dose streptozotocin injection and high fat diet for four weeks. Experimental groups were designed as follows: control, diabetic, restorative-NO treated diabetic and protective-NO treated diabetic. Intracellular action potentials (AP) and contractile activities were measured form left ventricular papillary muscle strips as well as histopathological examination of heart tissue and biochemical examinations of serum were performed. RESULTS: Type 2 diabetes induced AP prolongation was prevented with both ways of NO treatments. Moreover, treatments produced nearly complete restorations of diabetes-induced depressed amplitude and altered kinetics of contractile activities. In parallel to electrophysiological parameters, both histopathological and biochemical results indicates the NO induced benefi cial effects on the diabetes related alterations. CONCLUSION: Distillated Nerium oleander (NO) can be a highly potential therapeutic or preventive agent on the diabetes induced excitation-contraction coupling alterations (Tab. 3, Fig. 3, Ref. 23).
Yazarlar (6)
1
Murat Ayaz
2
F. Baba
3
N. Akgun
4
A. L. Baş
5
Kamil Üney
ORCID: 0000-0002-8674-4873
6
Burak Dik
Anahtar Kelimeler
Cardiomyopathy
Electrophysiology
Heart
Nerium oleander
Type II diabetes
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime