Scopus
YÖKSİS Eşleşti
Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves
Journal of Veterinary Pharmacology and Therapeutics · Kasım 2019
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves
Journal of Veterinary Pharmacology and Therapeutics · 2019 SCI-Expanded
PROFESÖR MAHMUT OK →
Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves
Journal of Veterinary Pharmacology and Therapeutics · 2019 SCI-Expanded
DOÇENT MERVE İDER →
Pharmacokinetics and bioavailability of cefquinome and ceftriaxone in premature calves
Journal of Veterinary Pharmacology and Therapeutics · 2019 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiKasım 2019
Cilt / Sayfa42 · 632-639
Scopus ID2-s2.0-85067614931
Özet
The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2 mg/kg) through IV or IM administration. The second group received CTX (20 mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high-performance liquid chromatography and noncompartmental methods. Mean pharmacokinetic parameters of CFQ and CTX following IV administration were as follows: elimination half-life (t1/2λz) 1.85 and 3.31 hr, area under the plasma concentration–time curve (AUC0–∞) 15.74 and 174 hr * μg/ml, volume of distribution at steady-state 0.37 and 0.45 L/kg, and total body clearance 0.13 and 0.12 L hr−1 kg−1, respectively. Mean pharmacokinetic parameters of CFQ and CTX after IM injection were as follows: peak concentration 4.56 and 25.04 μg/ml, time to reach peak concentration 1 and 1.5 hr, t1/2λz 4.74 and 3.62 hr, and AUC0–∞ 22.75 and 147 hr * μg/ml, respectively. The bioavailability of CFQ and CTX after IM injection was 141% and 79%, respectively. IM administration of CFQ (2 mg/kg) and CTX (20 mg/kg) can be recommended at 12-hr interval for treating infections caused by susceptible bacteria, with minimum inhibitory concentration values of ≤0.5 and ≤4 μg/ml, respectively, in premature calves. However, further research is indicated to assess the pharmacokinetic parameters following multiple doses of the drug in premature calves.
Yazarlar (6)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Ramazan Yildiz
3
Merve Ider
ORCID: 0000-0003-2928-5452
4
Feray Altan
5
M. Ok
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
bioavailability
cefquinome
ceftriaxone
pharmacokinetics
premature calves
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Dicle Üniversitesi
Diyarbakir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
5
Anahtar Kelime