Scopus
YÖKSİS Eşleşti
Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar)
Journal of Veterinary Pharmacology and Therapeutics · Ocak 2022
YÖKSİS Kayıtları
Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (\n <i>Alectoris chukar<\/i>\n )
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (Alectoris chukar)
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI
PROFESÖR KAMİL ÜNEY →
Effect of ketoprofen on intravenous pharmacokinetics of ganciclovir in chukar partridges (\n Alectoris chukar\n )
Journal of Veterinary Pharmacology and Therapeutics · 2021 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiOcak 2022
Cilt / Sayfa45 · 126-132
Scopus ID2-s2.0-85118292889
Özet
The aim of the study was to determine the effect of ketoprofen (2 mg/kg) on the intravenous pharmacokinetics of ganciclovir (10 mg/kg) in chukar partridges (Alectoris chukar). Eight clinically healthy partridges were used in the study. The study was performed in two periods using a cross-over design following a 15-day drug washout period. Plasma concentrations of ganciclovir were determined using the high-pressure liquid chromatography-ultraviolet detector and analyzed by non-compartmental analysis. The elimination half-life (t1/2ʎz), area under the concentration-time curve (AUC0-∞), total body clearance, and volume of distribution at steady state of ganciclovir were 1.63 h, 33.22 h*μg/ml, 0.30 L/h/kg, and 0.53 L/kg, respectively. Ketoprofen administration increased the t1/2ʎz and AUC0-∞ of ganciclovir by 78% and 108%, respectively, and while decreased ClT by 53%. The increased plasma concentration and prolonged elimination half-life of ganciclovir caused by ketoprofen may result in the prolonged duration of action and therapeutic effect of ganciclovir. However, the concomitant use requires determination of the pharmacokinetics of ketoprofen and the safety of both drugs.
Yazarlar (7)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
D. Durna Corum
4
O. Atik
5
Devran Coskun
ORCID: 0000-0003-1151-1861
6
A. Zhunushova
7
M. Elmas
Kurumlar
Afyon Kocatepe Üniversitesi
Afyonkarahisar Turkey
Kastamonu University
Kastamonu Turkey
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
Metrikler
2
Atıf
7
Yazar