Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
Polish Journal of Veterinary Sciences · Ocak 2022
YÖKSİS Kayıtları
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
Polish Journal of Veterinary Sciences · 2022 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
POLISH JOURNAL OF VETERINARY SCIENCES · 2022 SCI
PROFESÖR BÜNYAMİN TRAŞ →
The effects of dexamethasone and minocycline alone and combined with N-acetylcysteine and vitamin E on serum matrix metalloproteinase-9 and coenzyme Q10 levels in aflatoxin B1 administered rats
POLISH JOURNAL OF VETERINARY SCIENCES · 2022 SCI-Expanded
PROFESÖR BURAK DİK →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2022
Cilt / Sayfa25 · 419-427
Scopus ID2-s2.0-85138610251
Erişim🔓 Açık Erişim
Özet
This study aimed to determine the effects of dexamethasone and minocycline alone and combined treatment with N-acetylcysteine (NAC) and vitamin E on serum coenzyme Q10 (CoQ10) and matrix metalloproteinase-9 (MMP-9) levels in rats administered aflatoxin B1 (AFB1). The study was carried out on 66 male Wistar rats. Following the intraperitoneal (IP) administration of AFB1 at dose of 2 mg/kg, minocycline (45 and 90 mg/kg, IP) and dexamethasone (5 and 20 mg/kg, IP) were administered alone and combined with NAC (200 mg/kg, IP) and vitamin E (600 mg/kg, IP). CoQ10 and MMP-9 levels were analyzed using the HPLC-UV method and a commercial kit by ELISA, respectively. AFB1 increased MMP-9 level and decreased CoQ10 level compared to the control group. After dexamethasone and minocycline administration, there is no increase in CoQ10 level, which is caused by AFB1. However, dexamethasone and minocycline combined with NAC+vitamin E caused significant increases in CoQ10 levels. Dexamethasone and minocycline alone and combined with NAC+vitamin E decreased MMP-9 levels compared to the single AFB1 treated group. The use of MMPs inhibitors and oxidative stress-reducing agents is anticipated to be beneficial in the poisoning with AFB1.
Yazarlar (6)
1
B. Traş
2
H. Eser Faki
3
Zeynep Ozdemir Kutahya
4
Emre Bahcivan
5
Burak Dik
6
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
Aflatoxin B1
coenzyme Q10
matrix metalloproteinase-9
rat
treatment
Kurumlar
Amasya Üniversitesi
Amasya Turkey
Çukurova Üniversitesi
Adana Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
6
Yazar
5
Anahtar Kelime