Scopus
YÖKSİS Eşleşti
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics · Eylül 2022
YÖKSİS Kayıtları
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics · 2022 SCI-Expanded
PROFESÖR MAHMUT OK →
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI
PROFESÖR BÜNYAMİN TRAŞ →
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics · 2022 SCI-Expanded
DOÇENT MERVE İDER →
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves?
Journal of Veterinary Pharmacology and Therapeutics · 2022 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiEylül 2022
Cilt / Sayfa45 · 426-431
Scopus ID2-s2.0-85131926284
Özet
This study was aimed to determine the pharmacokinetics of antisecretory-acting racecadotril, used in the treatment of diarrhea in humans and dogs, following oral administration in both neonatal calves with healthy and neonatal calves with infectious diarrhea. The study was carried out on a total of 24 Holstein calves (2–20 days), of which 6 were healthy and 18 were infectious diarrhea. Calves with infectious diarrhea were divided into 3 groups according to the infectious agent (Escherichia coli, Cryptosporidium parvum, and rotavirus/coronavirus). Racecadotril was administered orally at 2.5 mg/kg dose to calves. The plasma concentrations of racecadotril and its main active metabolite (thiorphan) were determined using HPLC-UV. The pharmacokinetic parameters were analyzed using the non-compartmental method. In healthy calves, the t1/2ʎz, Cmax, Tmax, and AUC0-12 of racecadotril were determined 4.70 h, 377 ng/ml, 0.75 h, and 1674 h × ng/ml, respectively. In the plasma of calves with infectious diarrhea, racecadotril and thiorphan were only detected at the sampling time from 0.25 to 1.5 h. As in calves with infectious diarrhea, thiorphan in plasma was only detected in healthy calves from 0.25 to 1.5 h. Racecadotril showed a large distribution volume, rapid elimination, and low metabolism to thiorphan in healthy calves.
Yazarlar (8)
1
B. Traş
2
M. Ok
3
T. M. Parlak
4
Merve Ider
ORCID: 0000-0003-2928-5452
5
Ramazan Yildiz
6
H. Eser Faki
7
Zeynep Ozdemir Kutahya
8
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
calve
infectious diarrhea
pharmacokinetics
racecadotril
thiorphan
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Çukurova Üniversitesi
Adana Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
8
Yazar
5
Anahtar Kelime