Scopus
YÖKSİS Eşleşti
Pharmacokinetics and bioavailability of carprofen in sheep
Journal of Veterinary Pharmacology and Therapeutics · Kasım 2022
YÖKSİS Kayıtları
Pharmacokinetics and bioavailability of carprofen in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Pharmacokinetics and bioavailability of carprofen in sheep
JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS · 2022 SCI
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiKasım 2022
Cilt / Sayfa45 · 543-549
Scopus ID2-s2.0-85133070102
Özet
The aim of this study was to determine the pharmacokinetics and bioavailability of carprofen in sheep following single intravenous (IV), intramuscular (IM), subcutaneous (SC), and oral (PO) administrations of a parenteral formulation at a dose of 4 mg/kg. A total of eight sheep were used for the investigation. The study comprised four periods, according to a crossover design with a 21-day washout period between treatments. Plasma concentrations of carprofen were measured using HPLC-UV. Pharmacokinetic parameters were estimated by non-compartmental model analysis. Following IV administration, t1/2ʎz, ClT, and Vdss were 43.36 h, 1.98 ml/h/kg, and 121.36 ml/kg, respectively. The Cmax(obs) was 26.57 mg/ml for the IM, 23.76 mg/ml for the SC, and 15.90 mg/ml for the PO. The bioavailability following IM, SC, and PO administrations was 75.47%, 82.00%, and 62.51%, respectively. Plasma creatine kinase activity increased significantly at 3, 6, and 12 h following IM administration of carprofen. Despite differences in plasma concentrations and bioavailability among administration routes, carprofen at 4 mg/kg dose may provide the plasma concentration (>1.5 μg/ml) needed for analgesic effect during 144 h in all routes. However, because of the slow absorption rate after SC and PO routes, the IV route may be preferred primarily for the rapid onset in the analgesic and anti-inflammatory effect of carprofen in sheep. Despite the favorable kinetics, the muscle damage caused by IM injection limits use of carprofen via IM route.
Yazarlar (5)
1
Devran Coskun
ORCID: 0000-0003-1151-1861
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
M. Elmas
Anahtar Kelimeler
bioavailability
carprofen
pharmacokinetics
sheep
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
University of Hatay Mustafa Kemal
Hatay Turkey
Metrikler
3
Atıf
5
Yazar
4
Anahtar Kelime