Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice

Canadian Journal of Physiology and Pharmacology · Ocak 2023

YÖKSİS Kayıtları

Canadian Science Publishing · 2023 SCI-Expanded

PROFESÖR BÜNYAMİN TRAŞ →

Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice

Canadian Journal of Physiology and Pharmacology · 2023 SCI-Expanded

DOKTOR ÖĞRETİM ÜYESİ TUĞBA MELİKE PARLAK →

Vitamins E and A increase the passing of the P-gp substrate ivermectin into the brain in mice

Canadian journal of physiology and pharmacology · 2023 SCI-Expanded

PROFESÖR KAMİL ÜNEY →

Makale Bilgileri

DergiCanadian Journal of Physiology and Pharmacology

Yayın TarihiOcak 2023

Cilt / Sayfa101 · 475-480

DOI10.1139/cjpp-2023-0078

Scopus ID2-s2.0-85169503727

Özet This study aimed to determine the effect of administration of oral vitamins A and E at different doses on plasma and brain concentrations of ivermectin in mice. The study was carried out on 174 Swiss Albino male mice aged 8-10 weeks. After leaving six mice for method validation, the remaining mice were randomly divided into seven groups with equal numbers of animals. Mice received ivermectin (0.2 mg/kg, subcutaneous) alone and in combination with low (vitamin A: 4000 IU/kg; vitamin E: 35 mg/kg) and high (vitamin A: 30 000 IU/kg; vitamin E: 500 mg/kg) oral doses of vitamins A and E. The plasma and brain concentrations of ivermectin were measured using high-performance liquid chromatography-fluorescence detector. We determined that high doses of vitamins A and E and their combinations increased the passing ratio of ivermectin into the brain significantly. The high-dose vitamin E and the combination of high-concentration vitamins E andA significantly increased the plasma concentration of ivermectin (P < 0.05). The high-dose vitamins E andA and their high-dose combination increased the brain concentration of ivermectin by 3, 2, and 2.7 times, respectively. This research is the first in vivo study to determine the interaction between P-gp substrates and vitamins E and A.