Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration
Veterinary Sciences · Haziran 2023
YÖKSİS Kayıtları
Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration
Veterinary Sciences · 2023 SCI-Expanded
PROFESÖR MUAMMER ELMAS →
Effects of Temperature on the Pharmacokinetics, Tissue Residues, and Withdrawal Times of Doxycycline in Rainbow Trout (Oncorhynchus mykiss) following Oral Administration
Veterinary Sciences · 2023 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiVeterinary Sciences
Yayın TarihiHaziran 2023
Cilt / Sayfa10
Scopus ID2-s2.0-85163766241
Erişim🔓 Açık Erişim
Özet
The purpose of this study was to compare the pharmacokinetics, tissue residues, and withdrawal times of doxycycline after oral administration in rainbow trout reared at 10 and 17 °C. Fish received a 20 mg/kg oral dose of doxycycline after a single or 5-day administration. Six rainbow trout were used at each sampling time point for plasma and tissue samples, including liver, kidney, and muscle and skin. The doxycycline concentration in the samples was determined using high-performance liquid chromatography with ultraviolet detector. The pharmacokinetic data were evaluated by non-compartmental kinetic analysis. The WT 1.4 software program was used to estimate the withdrawal times. The increase of temperature from 10 to 17 °C shortened the elimination half-life from 41.72 to 28.87 h, increased the area under the concentration–time curve from 173.23 to 240.96 h * μg/mL, and increased the peak plasma concentration from 3.48 to 5.50 μg/mL. At 10 and 17 °C, the doxycycline concentration was obtained in liver > kidney > plasma > muscle and skin. According to the MRL values stated for muscle and skin in Europe and China (100 μg/kg) and in Japan (50 μg/kg), the withdrawal times of doxycycline at 10 and 17 °C were 35 and 31 days, respectively, for Europe and China and 43 and 35 days, respectively, for Japan. Since temperature significantly affected pharmacokinetic behavior and withdrawal times of doxycycline in rainbow trout, temperature-dependent dosing regimens and withdrawal times of doxycycline might be necessary.
Yazarlar (7)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
4
D. Durna Corum
5
Devran Coskun
ORCID: 0000-0003-1151-1861
6
Feray Altan
7
M. Elmas
Anahtar Kelimeler
doxycycline
oral pharmacokinetics
rainbow trout
temperature
tissue residue
withdrawal time
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Kastamonu University
Kastamonu Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
University of Hatay Mustafa Kemal
Antakya Turkey
Metrikler
6
Atıf
7
Yazar
6
Anahtar Kelime