Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Determination of temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in non-pregnant and pregnant goats
Journal of Veterinary Pharmacology and Therapeutics · Ocak 2024
YÖKSİS Kayıtları
Determination of temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in non-pregnant and pregnant goats
Journal of Veterinary Pharmacology and Therapeutics · 2024 SCI
DOÇENT SAKİNE ÜLKÜM ÇİZMECİ →
Determination of temporal changes in hepatic drug-oxidizing capacity using plasma metabolite/caffeine ratios in non-pregnant and pregnant goats.
Journal of veterinary pharmacology and therapeutics · 2024 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiJournal of Veterinary Pharmacology and Therapeutics
Yayın TarihiOcak 2024
Cilt / Sayfa47 · 28-35
Scopus ID2-s2.0-85164817140
Erişim🔓 Açık Erişim
Özet
Caffeine (CF) is a metabolic probe drug used in the determination of the hepatic drug-oxidizing capacity. The aim of this study was to investigate temporal changes in the hepatic drug-oxidizing capacity using plasma metabolite/CF ratios in non-pregnant goats (n = 11) and pregnant goats (n = 23). CF (5 mg/kg, intravenous) was administered in six periods (Period 1–6) with 45 days between two periods. The plasma levels of CF and its metabolites, theophylline (TP), theobromine (TB) and paraxanthine (PX), were determined by HPLC-UV. To evaluate hepatic drug-oxidizing capacity in terms of enzymes that play a role in CF metabolism, the plasma metabolic ratios including TB/CF, PX/CF, TP/CF and TB + PX + TP/CF were determined at 10 h following CF administration. Plasma metabolite/CF ratios were similar between non-pregnant and pregnant goats. However, plasma metabolite/CF ratios in Period 3 (45 days in pregnant goats) were significantly higher than those other periods in both pregnant and non-pregnant goats. The effect of pregnancy may not be observed on drugs that are substrates of enzymes involved in CF metabolism in goats.
Yazarlar (5)
1
Feray Altan
2
Sakine Ulkum Cizmeci
3
Ayse Merve Kose
4
Orhan Corum
ORCID: 0000-0003-3168-2510
5
Kamil Üney
ORCID: 0000-0002-8674-4873
Anahtar Kelimeler
caffeine
goats
hepatic drug-oxidizing capacity
pregnancy
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey