Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations
Veterinary Medicine and Science · Mayıs 2024
YÖKSİS Kayıtları
Pharmacokinetic behaviour and pharmacokinetic–pharmacodynamic integration of doxycycline in rainbow trout (Oncorhynchus mykiss) after intravascular, intramuscular and oral administrations
Veterinary Medicine and Science · 2024 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Pharmacokinetic behaviour and pharmacokinetic-pharmacodynamic integration of doxycycline in rainbow trout (<i>Oncorhynchus mykiss</i>) after intravascular, intramuscular and oral administrations
VETERINARY MEDICINE AND SCIENCE · 2024 SCI
PROFESÖR MUAMMER ELMAS →
Makale Bilgileri
DergiVeterinary Medicine and Science
Yayın TarihiMayıs 2024
Cilt / Sayfa10
Scopus ID2-s2.0-85188418176
Erişim🔓 Açık Erişim
Özet
Objective: Doxycycline (DO) has been used in fish for a long time, but there are some factors that have not yet been clarified regarding its pharmacokinetic (PK) and pharmacodynamic (PD) properties. Therefore, the aim of this study was to investigate the PK and PK/PD targets of DO after 20 mg/kg intravascular (IV), intramuscular (IM) and oral (OR) gavage administration in rainbow trout (Oncorhynchus mykiss). Methods: Plasma samples were collected at specific time points and subsequently analysed by HPLC-ultraviolet. The PK/PD indices were calculated based on the MIC90 (Aeromonas hydrophila and Aeromonas sobria) values obtained for the respective bacteria and the PK parameters obtained for DO following both IM and OR administration. Results: After IV administration, the elimination half-life (t1/2ʎz), area under the concentration vs. time curve (AUC), apparent volume of distribution at steady-state and total body clearance of DO were 34.81 h, 723.82 h µg/mL, 1.24 L/kg and 0.03 L/kg/h, respectively. The t1/2λz of the DO was found to be 37.39 and 39.78 h after IM, and OR administration, respectively. The bioavailability was calculated 57.02% and 32.29%, respectively, after IM and OR administration. The MIC90 of DO against A. hydrophila and A. sobria was 4 µg/mL. The PK/PD integration showed that DO (20 mg/kg dose) for A. hydrophila and A. sobria with MIC90 ≤4 µg/mL achieved target AUC/MIC value after IM administration. Conclusions: These results suggest that when rainbow trout was treated with 20 mg/kg IV and IM administered DO, therapeutically effective concentrations were reached in the control of infections caused by A. hydrophila and A. sobria.
Yazarlar (8)
1
Feray Altan
2
Orhan Corum
ORCID: 0000-0003-3168-2510
3
D. Durna Corum
4
Kamil Üney
ORCID: 0000-0002-8674-4873
5
Ertugrul Terzi
ORCID: 0000-0003-2811-6497
6
Soner Bilen
ORCID: 0000-0001-9459-8178
7
Adem Yavuz Sonmez
ORCID: 0000-0002-7043-1987
8
M. Elmas
Anahtar Kelimeler
Aeromonas hydrophila
Aeromonas sobria
doxycycline
pharmacokinetics
PK–PD integration
rainbow trout
Kurumlar
Dokuz Eylül Üniversitesi
Izmir Turkey
Kastamonu University
Kastamonu Turkey
Mustafa Kemal Üniversitesi
Antakya Turkey
Selçuk Üniversitesi
Selçuklu Turkey