Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Plasma and Milk Pharmacokinetics and Estimated Milk Withdrawal Time of Tolfenamic Acid in Lactating Sheep
Veterinary Medicine and Science · Kasım 2024
YÖKSİS Kayıtları
Plasma and Milk Pharmacokinetics and Estimated Milk Withdrawal Time of Tolfenamic Acid in Lactating Sheep
VETERINARY MEDICINE AND SCIENCE · 2024 SCI
PROFESÖR MUAMMER ELMAS →
Plasma and Milk Pharmacokinetics and Estimated Milk Withdrawal Time of Tolfenamic Acid in Lactating Sheep.
Veterinary medicine and science · 2024 SCI-Expanded
PROFESÖR KAMİL ÜNEY →
Makale Bilgileri
DergiVeterinary Medicine and Science
Yayın TarihiKasım 2024
Cilt / Sayfa10
Scopus ID2-s2.0-85204912909
Erişim🔓 Açık Erişim
Özet
Objective: This study aimed to investigate the plasma and milk pharmacokinetics, as well as the withdrawal time (WT) from milk of tolfenamic acid (2 and 4 mg/kg) following intravenous (IV) administration to eight healthy lactating Akkaraman sheep. Methods: The trial was conducted in two periods in accordance with a crossover pharmacokinetic design. The concentrations of tolfenamic acid in the plasma and milk were determined using high-pressure liquid chromatography and evaluated using non-compartmental analysis. The WT of tolfenamic acid in milk was calculated using the WT 1.4 software. Results: Compared to the 2 mg/kg dose, plasma volume of distribution at steady state (from 0.43 to 0.50 L/kg), terminal elimination half-life (from 2.41 to 4.14 h) and dose-normalized area under the plasma concentration–time curve (AUC0−∞, from 9.46 to 30.11 h µg/mL) increased, whereas total body clearance (from 0.21 to 0.13 L/h/kg) decreased at the 4 mg/kg dose. The peak milk concentration (Cmax) and AUC0−∞ values in milk were 0.26 µg/mL and 0.28 h µg/mL, respectively, for 2 mg/kg, and 0.43 µg/mL and 0.55 h µg/mL, respectively, for 4 mg/kg. Although the dose-normalized Cmax of milk decreased depending on the dose, no difference was observed in dose-normalized AUC0−∞. The AUC0−∞ milk/AUC0−∞ plasma ratio was 0.03 for 2 mg/kg and 0.02 for 4 mg/kg. The WT values calculated for milk at dosages of 2 and 4 mg/kg were 3 and 4 h, respectively. Conclusions: A decrease in plasma elimination and an increase in plasma concentration of tolfenamic acid were observed depending on the dose. Tolfenamic acid lowly passed into sheep's milk at 2 and 4 mg/kg doses. This study may provide valuable information for clinicians’ decision-making processes.
Yazarlar (6)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
Kamil Üney
ORCID: 0000-0002-8674-4873
3
Devran Coskun
ORCID: 0000-0003-1151-1861
4
D. Durna Corum
5
Gul Cetin
6
M. Elmas
Anahtar Kelimeler
lactating sheep
milk
pharmacokinetics
tolfenamic acid
withdrawal time
Kurumlar
Erzincan Binali Yıldırım Üniversitesi
Erzincan Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Siirt Üniversitesi
Siirt Turkey
University of Hatay Mustafa Kemal
Antakya Turkey