Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: A longitudinal study
Polish Journal of Veterinary Sciences · Ocak 2021
YÖKSİS Kayıtları
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
PROFESÖR MEHMET MADEN →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
PROFESÖR RAMAZAN ÇÖL →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
PROFESÖR MUSTAFA ARICAN →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
PROFESÖR BÜNYAMİN TRAŞ →
The clinical efficacy of pentoxifylline and l-glutamine on ischemia and reperfusion injury in cattle with displaced abomasum: a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
DOÇENT MERVE İDER →
The clinical efficacy of pentoxifylline
and l-glutamine on ischemia and reperfusion
injury in cattle with displaced abomasum:
a longitudinal study
Polish Journal of Veterinary Sciences · 2021 SCI-Expanded
DOÇENT KURTULUŞ PARLAK →
Makale Bilgileri
DergiPolish Journal of Veterinary Sciences
Yayın TarihiOcak 2021
Cilt / Sayfa24 · 595-605
Scopus ID2-s2.0-85125002422
Erişim🔓 Açık Erişim
Özet
This study aimed to assess the clinical efficacy of pentoxifylline (PTX) and L-glutamine (L-Gln) treatment on ischemia and reperfusion (I/R) injury in the abomasal tissue, acute phase response (APR), oxidative stress (OS), cytokine response, hemostatic, and coagulation disorders in the 96-h period before and after surgery in displaced abomasum (DA) cases. The study sample consisted of 48 dairy cows with DA that were categorized into four groups as group S (Sham group) (9 Left displaced abomasum (LDA)+3 Right displaced abomasum (RDA), group P (PTX) (10 LDA+2 RDA), group G (L-Gln) (10 LDA+2 RDA), and group P+G (PTX+L-Gln) (10 LDA+2 RDA). Acute-phase protein (Haptoglobin), oxidative stress indicators (malondialdehyde, nitric oxide, and glutathione), cytokines (tumor necrosis factor (TNF)-α and interleukin-1β (IL-1β), coagulation factors (D-Dimer, Antithrombin (ATIII), Thrombin-antithrombin complex, Plasminogen activator inhibitor-1), and enzyme activities (lactate dehydrogenase, gamma-glutamyl transferase, sorbitol dehydrogenase, glutamate dehydrogenase, adenosine deaminase, myeloperoxidase, and creatine phosphokinase) in blood serum samples and coagulometric analyses of blood plasma were performed in samples taken before the operation and at 30 and 60 min and 2, 5, 10, 24, 48, 72, and 96 h after the operation. In DA cases, while post-operative treatment procedures with PTX and L-Gln were effective in decreasing APR and OS, these were ineffective in prohibiting the inflammatory response coordinated by cytokines. For the treatment and prevention of I/R injury in the DA cases, PTX and L-Gln procedures hold promise with their effects on APR, OS, and hemostatic dysfunction. Additional treatment procedures are required for the suppression of inflammatory response, and the effectiveness of preconditioning treatment may be evaluated.
Yazarlar (7)
1
Mehmet Maden
2
Ramazan Yildiz
3
Ramazan Col
4
Mustafa Arican
ORCID: 0000-0001-8180-135X
5
Merve Ider
ORCID: 0000-0003-2928-5452
6
Kurtuluş Parlak
ORCID: 0000-0002-8656-037X
7
B. Traş
Anahtar Kelimeler
Abomasal displacement
Acute phase response
Cytokine response
Dairy cow
Hemostatic dysfunction
Oxidative stress
Kurumlar
Burdur Mehmet Akif Ersoy Üniversitesi
Burdur Turkey
Selçuk Üniversitesi
Selçuklu Turkey