Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs
Journal of Veterinary Medical Science · Ocak 2023
YÖKSİS Kayıtları
Comparison of Some Cytokines, Acute Phase Proteins and Citrulline Levels in Healthy and Canine Distemper Infected Dogs
Journal of Veterinary Medical Science · 2023 SCI-Expanded
DOÇENT IRMAK DİK →
Comparison of some cytokines, acute phase proteins and citrulline levels in healthy and canine distemper infected dogs
Japanese Society of Veterinary Science · 2023 SCI-Expanded
DOÇENT DURMUŞ HATİPOĞLU →
Makale Bilgileri
DergiJournal of Veterinary Medical Science
Yayın TarihiOcak 2023
Cilt / Sayfa85 · 76-82
Scopus ID2-s2.0-85146128612
Erişim🔓 Açık Erişim
Özet
Canine distemper virus (CDV) is the etiological agent of severe disease in domestic and wild carnivores. Clinical diagnosis of CDV is challenging because of its similarity to other canine respiratory and intestinal diseases. We aimed to determine certain cytokine (interleukin [IL]-1β, IL-2, IL-4, IL-6, IL-10, and tumor necrosis factor-α [TNF-α]), interferon (IFN)-γ, canine serum amyloid A (SAA), and canine citrulline (CIT) levels for the first time in CDV-positive dogs. For this purpose, 10 CDV-positive dogs with compatible clinical findings (i.e., neurological symptoms such as tremors and myoclonus, ocular and nasal discharge, and wheezing) and 10 healthy dogs based on the clinical examinations and rapid test results were enrolled. It was observed that the CIT, INF-γ, IL-1β, IL-2, IL-6, and TNF-α levels were significantly decreased in the CDV-positive dogs than that of the healthy ones (P<0.05). As a result, it was observed that CDV causes immunosuppression and accordingly, the inflammatory response might cause decreased cytokine and acute-phase protein synthesis. Therefore, it was concluded that further investigation of inflammatory pathways and CIT interactions may provide crucial clinical information at different stages of CDV, and aforementioned parameters may serve as important biomarkers for CDV in terms of demonstrating the presence of immunosuppression.
Yazarlar (3)
1
Irmak Dik
ORCID: 0000-0003-2516-9489
2
Durmus Hatipoglu
ORCID: 0000-0003-3790-7821
3
Erdem Gülersoy
ORCID: 0000-0001-8511-0150
Anahtar Kelimeler
canine distemper virus
citrulline
cytokines
dog
serum amyloid A
Kurumlar
Harran Üniversitesi
Sanliurfa Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
1
Atıf
3
Yazar
5
Anahtar Kelime