Scopus
YÖKSİS Eşleşti
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
Urologic Oncology: Seminars and Original Investigations · Ocak 2020
YÖKSİS Kayıtları
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS · 2020 SSCI
PROFESÖR SERDAR GÖKTAŞ →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
urologic oncology: seminars and original investigations · 2020 SCI-Expanded
PROFESÖR ÖZCAN KILIÇ →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS · 2019 SCI-Expanded
PROFESÖR ÖZCAN KILIÇ →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
urologic oncology: seminars and original investigations · 2020 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS · 2019 SCI-Expanded
PROFESÖR ZELİHA ESİN ÇELİK →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
urologic oncology: seminars and original investigations · 2020 SCI-Expanded
DOÇENT EMRE ALTINTAŞ →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
Urologic Oncology: Seminars and Original Investigations · 2020 SCI-Expanded
DOÇENT EMRE ALTINTAŞ →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS · 2019 SCI-Expanded
PROFESÖR MEHMET KAYNAR →
Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS · 2020 SSCI
PROFESÖR MEHMET KAYNAR →
Makale Bilgileri
DergiUrologic Oncology: Seminars and Original Investigations
Yayın TarihiOcak 2020
Cilt / Sayfa38 · 6.e17-6.e22
Scopus ID2-s2.0-85074541267
Özet
Objective: To determine the relationship between RING-box protein 1 (RBX-1) expression and renal cell carcinoma (RCC) with prognostic factors. Methods: A total of 88 patients who underwent radical/partial nephrectomy between January 2009 and January 2016 have been included in our study. The age, gender, tumor location, tumor size, and tumor-node-metastasis stage of each patient was evaluated. From the best sections in hematoxylin-eosin stained pathology preparations, tumor histological subtype, Fuhrman nuclear grade, lymphovascular invasion, renal artery/vein invasion, capsule invasion, perirenal fatty tissue invasion, and tumor grade were evaluated. Participants were divided into 2 groups according to Fuhrman grade. Fuhrman grades 1 to 2 comprised Group 1, and Fuhrman grades 3 to 4 comprised Group 2. An immunoreactivity scoring system was used to evaluate RBX-1 expression. Results: Upon examining all histological subtypes together, it was observed that RBX-1 expression was statistically higher in Group 2 compared to Group 1 (P < 0.008). Upon examining clear RCC cases, it was observed again that Group 2 had a higher RBX-1 expression than Group 1 (P < 0.009). RBX-1 expression was not associated with clinical-pathological parameters including tumor grade, lymphovascular invasion, capsule invasion, or perirenal invasion. Conclusion: RBX-1 expression is closely associated with a highly important prognostic factor in RCC—Fuhrman grade—and it shows promise as a prognostic marker. Further studies are required to reveal the importance of RBX-1 in RCC prognosis and treatment.
Yazarlar (7)
1
Emre Altıntaş
ORCID: 0000-0002-6797-3937
2
Mehmet Kaynar
ORCID: 0000-0002-6957-9060
3
Zeliha Esin Celik
4
Murat Çelik
5
Ozcan Kilic
6
Murat Akand
7
Serdar Goktas
ORCID: 0000-0001-6538-7187
Anahtar Kelimeler
Fuhrman grading system
Immunohistochemistry
Renal cell cancer
Ring box protein-1
Kurumlar
Akcakale State Hospital
Sanliurfa Turkey
Kars Harakani State Hospital
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
4
Atıf
7
Yazar
4
Anahtar Kelime