Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Does clozapine really affect bone mineral density? An experimental study
Journal of Orthopaedic Surgery and Research · Aralık 2021
YÖKSİS Kayıtları
Does clozapine really affect bone mineral density? An experimental study
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH · 2021 SCI-Expanded
PROFESÖR MEMDUHA AYDIN →
Does clozapine really affect bone mineral density? An experimental study
Journal of Orthopaedic Surgery and Research · 2021 SCI-Expanded
PROFESÖR BAHATTİN KEREM AYDIN →
Does clozapine really affect bone mineral density? An experimental study
Journal of Orthopaedic Surgery and Research · 2021 SCI-Expanded
DOÇENT MURAT ÇELİK →
Does clozapine really affect bone mineral density? An experimental study
Journal of Orthopaedic Surgery and Research · 2021 SCI-Expanded
DOÇENT MURAT ÇELİK →
Does clozapine really affect bone mineral density? An experimental study
Journal of Orthopaedic Surgery and Research · 2021 SCI-Expanded
DOÇENT HAKAN CEBECİ →
Does clozapine really affect bone mineral density? An experimental study
Springer Science and Business Media LLC · 2021 SCI-Expanded
DOÇENT SELİM SAFALI →
Makale Bilgileri
DergiJournal of Orthopaedic Surgery and Research
Yayın TarihiAralık 2021
Cilt / Sayfa16
Scopus ID2-s2.0-85114889368
Erişim🔓 Açık Erişim
Özet
Purpose: The aim of this study was to investigate the effect of clozapine use on bone tissue by applying computerized tomography, dual-energy X-ray absorptiometry, and histological and biomechanical analyses in an experimental rat model. Methods: Sixteen female Wistar Albino rats were included in this study. These animals were divided into two groups: the control group and the clozapine group. The animals in the clozapine group received 10 mg/kg clozapine, and the animals in the control group received tap water by oral gavage daily for 28 days. After sacrification, the femurs of the rats were used for radiologic, histologic, dual-energy X-ray absorptiometry, and biomechanical evaluations. Results: Although the mean values of the clozapine group were higher in terms of histological, bone mineral density, and biomechanical evaluations, the statistical analyses were not significantly different. Conclusion: Clozapine use did not affect bone density in the rats. Clozapine can be the preferred treatment for patients with schizophrenia to avoid osteoporosis. It will be necessary to conduct further long-term follow-up and controlled studies in animals and humans to confirm these findings.
Yazarlar (7)
1
B. K. Aydin
2
Selim Safali
3
Memduha Aydin
4
Umran Egilmez
5
Hakan Cebeci
6
Murat Çelik
7
Ummuhan Abdulrezzak
Anahtar Kelimeler
Bone mineral density
Clozapine
Osteoporosis
Rat
Schizophrenia
Kurumlar
Erciyes University, Faculty of Medicine
Kayseri Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
2
Atıf
7
Yazar
5
Anahtar Kelime