Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey
Journal of Research in Pharmacy · Ocak 2022
YÖKSİS Kayıtları
Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey
JOURNAL OF RESEARCH IN PHARMACY · 2022 SCI-Expanded
PROFESÖR YÜKSEL KAN →
Chemical composition and in vitro mutagenic, antioxidant and anti-inflammatory activities of Lavandula angustifolia Mill. essential oil from Turkey
Journal of Research in Pharmacy · 2022 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ İREM AYRAN ÇOLAK →
Chemical composition and in vitro mutagenic, antioxidant
and anti-inflammatory activities of Lavandula angustifolia
Mill. essential oil from Turkey
Journal of research in pharmacy (online) · 2022 ESCI
DOKTOR ÖĞRETİM ÜYESİ SADİYE AYŞE ÇELİK →
Makale Bilgileri
DergiJournal of Research in Pharmacy
Yayın TarihiOcak 2022
Cilt / Sayfa26 · 781-789
Scopus ID2-s2.0-85133896597
Erişim🔓 Açık Erişim
Özet
The essential oil obtained from Lavandula angustifolia Mill. (Lavander) has many pharmacological effects, including antioxidant, antifungal, antibacterial and carminative effects. Lavandula angustifolia essential oil (LEO) contains monoterpene compounds, mainly linalool and linalyl acetate and various phenolic acids such as caffeic acid, vanillic acid, ferulic acid and chlorogenic acid. The hydrodistillation of the aerial parts of L. angustifolia produced a pale yellow oil. Gas chromatography-Gas chromatography/Massspectrometry (GC-GC/MS) results showed that LEO contains monoterpene alcohols that primarily include linalool (35.91%), 4-Terpineol (6.10%), α-Terpineol (4.49%) and lavandulol (2.49%). As a result of the cytotoxicity analysis of LEO, the IC50 value was found to be 0.372 mg/mL. LEO was found to be non-mutagenic against the bacterial test strain Salmonella typhimurium TA 98 with S9 fraction while the highest concentration (9.58 mg/mL) was found to be either mutagenic or cytotoxic against TA 98 without S9 fraction. The essential oil’s antioxidant capacity was found 6.522±0.069 mg/mL while the total phenolic content was 1.22±0.04 mg GAE/g extract (Gallic acid equivalent/g extract). Anti-inflammatory activity of LEO was 1.238± 0.026 mg/mL while that of indomethacine was 0.022±0.003 mg/mL. In conclusion, when the results are evaluated in terms of in vitro biological activities, LEO can be considered as a potential herbal product with active compounds that should be examined in future studies.
Yazarlar (9)
1
Pınar Sinem Omurtag Özgen
2
Sevde Nur Biltekin
3
Tuğba İduğ
4
Caglar Macit
5
İrem Ayran
6
Sadiye Ayşe Çelik
ORCID: 0000-0002-0765-642X
7
Şükran Kültür
8
Yüksel Kan
9
Gülden Zehra Omurtag
Anahtar Kelimeler
antioxidant activity
cytotoxicity
essential oil
Lavandula angustifolia
mutagenity
Kurumlar
İstanbul Medipol Üniversitesi
Istanbul Turkey
Istanbul Üniversitesi
Istanbul Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
6
Atıf
9
Yazar
5
Anahtar Kelime