Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Halofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colon
Indian Journal of Animal Research · Ocak 2017
YÖKSİS Kayıtları
Halofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colon
Indian Journal of Animal Research · 2017 SCI-Expanded
PROFESÖR ENVER YAZAR →
Halofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colon
Indian Journal of Animal Research · 2017 SCI-Expanded
PROFESÖR ÖZGÜR ÖZDEMİR →
Makale Bilgileri
DergiIndian Journal of Animal Research
Yayın TarihiOcak 2017
Cilt / Sayfa51 · 1120-1124
Scopus ID2-s2.0-85039070105
Erişim🔓 Açık Erişim
Özet
The aim of this research was to investigate the effect of halofuginone on the progression of azoxymethane-induced colon cancer in rats. A total of 38 male Wistar albino rats were divided into 4 groups: Control (n=8), Halofuginone (n=10, 0.4 mg/ kg, PO, SID), Cancer (n=10, azoxymethane, 15 mg/kg, IP, once a week for two weeks) and Cancer + Halofuginone (n=10). After 18 weeks, blood samples were taken under anesthesia and all animals were sacrificed. Aberrant crypt foci in the colon were stained with methylene blue. Blood cytokines, thiobarbituric acid reactive substances, 13,14-dihydro-15-keto-prostaglandin F2α levels, hemogram and biochemical values were measured. The tumor necrosis factor-a level in the Cancer group was higher (P<0.05) than in other groups, while higher numbers of aberrant crypt foci were found in the Cancer group compared with the Cancer + Halofuginone group (P<0.05). In summary, it may be stated that halofuginone may warrant evaluation as a supportive drug in the treatment of colon cancer in the future.
Yazarlar (3)
1
Orhan Corum
ORCID: 0000-0003-3168-2510
2
O. Ozdemir
3
E. Yazar
Anahtar Kelimeler
Aberrant crypt foci
Colon cancer
Cytokines
Halofuginone
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
2
Atıf
3
Yazar
4
Anahtar Kelime