Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q2
Does vanillic acid affect fracture healing? An experimentstudy in a rat model of femur fracture
Journal of Applied Biomedicine · Ocak 2024
YÖKSİS Kayıtları
Does vanillic acid affect fracture healing? An experimental study in a rat model of femur fracture
Journal of Applied Biomedicine · 2024 SCI-Expanded
Doç. Dr. MURAT ÇELİK →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The Effect of Different Doses of Zinc Supplementation on Serum Element and Lactate Levels in Elite Volleyball Athletes.
2017 ISSN: 1214-021X SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
Does vanillic acid affect fracture healing? An experimental study in a rat model of femur fracture
2024 ISSN: 1214-021X SCI-Expanded Q3
Doç. Dr. MURAT ÇELİK →
Makale Bilgileri
ISSN1214021X
Yayın TarihiOcak 2024
Cilt / Sayfa22 · 67-73
Scopus ID2-s2.0-85197018370
Erişim🔓 Açık Erişim
Özet
Background and objectives: We aimed to determine the effects of vanillic acid (VA) on fracture healing radiologically, histologically, immunohistochemically, and biomechanically using a rat femur open fracture injury model. Methods: 32 male Wistar-Albino rats were used and divided into two groups: the study group (VA) and the control group. From the time they were operated on until they were sacrificed, the rats in the study group were given 100 mg/kg/day VA by oral gavage. After sacrification, the femurs were analyzed. Results: It was observed that the Huo histological scoring was significantly higher in the VA group (p = 0.001), and the ratio of the amount of callus tissue compared to intact bone tissue was significantly higher. While no significant difference was observed in immunohistochemical H-scores in ColI antibody staining (p = 1.000), a borderline significant difference in favor of VA was observed in ColIII antibody staining (p = 0.078). In biomechanical analysis, failure load (N), total energy (J), maximum stress (MPa), and stiffness (N/mm) measurements were significantly higher in the VA group (p = 0.040, p = 0.021, p = 0.015, and p = 0.035, respectively). Conclusion: It has been observed that VA, with its antioxidative properties, increases fracture healing in rats, in which an open fracture model was created. We are hopeful that such an antioxidant, which is common in nature, will increase fracture healing. Since this study is the first to examine the effect of VA on fracture healing, further studies are needed.
Yazarlar (6)
1
Ahmet Yurteri
2
Numan Mercan
3
Mehmet Kılıç
4
Murat Çelik
5
Fatih Doğar
6
Ahmet Yıldırım
Anahtar Kelimeler
Angelica sinensis
Fracture union
Open fracture
Phenolic compounds
Vanillic acid
Kurumlar
Kahramanmaraş Necip Fazıl City Hospital
Kahramanmaras Turkey
Kahramanmaras Sütçü Imam Üniversitesi
Kahramanmaras Turkey
Konya City Hospital
Konya Turkey
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Applied Biomedicine
Q2
OA
SJR Skoru0,507
H-Index42
YayıncıUniversity of South Bohemia in Ceske Budejovice Faculty of Health and Social Sciences
ÜlkeCzech Republic
Agricultural and Biological Sciences (miscellaneous) (Q2)
Artificial Intelligence (Q2)
Biochemistry, Genetics and Molecular Biology (miscellaneous) (Q2)
Immunology and Microbiology (miscellaneous) (Q2)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous) (Q2)
Biomedical Engineering (Q3)
Health, Toxicology and Mutagenesis (Q3)
Medicine (miscellaneous) (Q3)
Neuroscience (miscellaneous) (Q3)
Metrikler
3
Atıf
6
Yazar
5
Anahtar Kelime