Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q4
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
Revista Cientifica De La Facultad De Veterinaria · Ocak 2022
YÖKSİS Kayıtları
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
Revista Científica de la Facultad de Ciencias Veterinarias · 2022 SCI-Expanded
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
REVISTA CIENTIFICA-FACULTAD DE CIENCIAS VETERINARIAS · 2022 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZGÜR ÖZDEMİR →
Effect of Tarantula cubensis alcoholic extract and Nerium oleander distillate on cell proliferation markers in colon carcinogenesis
2022 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. MEHMET TUZCU →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded Q4
Arş. Gör. ZEYNEP ÇELİK KENAR →
Investigation with Real-Time PCR and Histopathology on the presence of H. felis, H. heilmannii and H. pylori in dogs
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
Determination of Embryotoxic effects of Atipamezole using in ovo model
2023 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
Evaluation of tumor necrosis Factor Alpha, Interferon Gamma, Procalcitonin and Neopterin levels in Brucella seropositive cattle
2023 ISSN: 0798-2259 SCI-Expanded
Doç. Dr. NEVİN TUZCU →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ÖZLEM DERİNBAY EKİCİ →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 Google scholar, sci, EBSCO, SCİ ELO, DOAJ, Latindex
Prof. Dr. AHMET LEVENT BAŞ →
Determination of the embryotoxic effect of Metronidazole using an in ovo model
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN KIZILAY →
ELISA–based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 CABI
Prof. Dr. OĞUZHAN AVCI →
ELISA-based Point Prevalence of enteropathogens in diarrheic calves in Central Anatolia Region of Turkey
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. NERMİN IŞIK USLU →
Effect of Tarantula cubensis alcohol extract and Capecitabin combine in Colorectal Cancer rats
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. AHMET LEVENT BAŞ →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2023 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ZAFER SAYIN →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ASLI BALEVİ →
Morphometric investigation of the effects of Azoxymethane, Diallyl disulfide and corn oil use on humerus and femur development in rats
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi SEDAT AYDOĞDU →
Microbiological characterization and genetic analysis of bacteria isolated from blood cultures and fecal samples in calves with symptoms of septicemia and diarrhea
2024 ISSN: 0798-2259 SCI-Expanded Q4
Doç. Dr. ALİ USLU →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Prof. Dr. ENDER ERDOĞAN →
Protective Effect of Silymarin and Mitoquinone (MitoQ) Aganist Hepatotoxicity of Cadmium Telluride Quantum Dot (CdTe QDs) Nanoparticles in Mice
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
Pathological and biochemical investigation of the effects of Silybum marianum against Methomyl damage in broiler liver
2024 ISSN: 0798-2259 SCI-Expanded
Prof. Dr. ERTAN ORUÇ →
Effect of propolis on pyruvate kinase and superoxide dismutase activities in doxorubicin–induced tissue damage: Molecular docking analysis
2024 ISSN: 0798-2259 SCI-Expanded Q4
Dr. Öğr. Üyesi HARUN YONAR →
Makale Bilgileri
ISSN07982259
Yayın TarihiOcak 2022
Cilt / Sayfa32
Scopus ID2-s2.0-85172862145
Erişim🔓 Açık Erişim
Özet
Colorectal Cancer (CRC) is defined as colon and rectum cancer and is among the major causes of mortality in developed Countries. Tarantula cubensis alcoholic extract (TCAE) and Nerium oleander distillate (NOD) are reported to have anticancer and antioxidative activity. In this study, it was aimed to research the impact on cell proliferation markers of TCAE and NOD given simultaneously in experimental colon cancer. A total of 24 rats, 6 in each group, were used in the study. Cancer Control (CC): Azoxymethane was administered at the beginning of the experiment at a dose of 15 miligrams (mg)· kilograms-1 (kg), (Subcutaneous, SC) twice, with an interval of a week (wk), to induce cancer. CC+TCAE: the dosage of Azoxymethane administered was 15 mg·kg-1 (SC) twice a wk at the beginning of the experiment, while in the case of TCAE, it was 0.2 mL·kg-1 (SC) once a wk for 18 wk from the beginning of the experiment. Fifteen mg·kg-1 (SC) of Azoxymethane was administered twice at one-wk intervals at the beginning of the experiment to the CC+NOD group, and NO distillate (NOD) was given with water throughout the experiment. Afterwards, animals were euthanized under appropriate conditions, paraffin blocks formed from colon tissues, histochemical AgNOR (Silverstained nucleolar organizer regions), and immunohistochemical PCNA (proliferating cell nuclear antigen) stainings were performed. In the study, immunohistochemically, PCNA scores and AgNOR count per nucleus (AgNCI) were significantly decreased in C-TCAE and C-NOD groups (P<0.001). AgNOR Area index (AgNAI) (P<0.01), Core Area Index (CAI) (P<0.05), and AgNOR Area index/Core Area Index (AgNAI/CAI) (P<0.01) scores were significantly decreased in the C-TCAE group. As a result, it was concluded that both TCAE and NOD are effective as chemopreventive drugs and that TCAE presents a more pronounced antiproliferative effect than NOD.
Yazarlar (3)
1
O. Ozdemir
2
G. Akcakavak
3
Mehmet Tuzcu
Anahtar Kelimeler
AgNOR
Azoxymethane
immunohistochemistry
pathology
PCNA
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Revista Cientifica de la Facultad de Veterinaria
Q4
OA
SJR Skoru0,138
H-Index16
YayıncıUniversidad del Zulia, Facultad de Ciencias Veterinarias
ÜlkeVenezuela
Animal Science and Zoology (Q4)
Food Science (Q4)
Immunology and Microbiology (miscellaneous) (Q4)
Veterinary (miscellaneous) (Q4)
Metrikler
12
Atıf
3
Yazar
5
Anahtar Kelime