Scopus
YÖKSİS Eşleşti
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats
Toxicology Mechanisms and Methods · Ocak 2024
YÖKSİS Kayıtları
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats
Toxicology Mechanisms and Methods · 2024 SCI
PROFESÖR FİRUZE KURTOĞLU →
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats
Toxicology Mechanisms and Methods · 2024 SCI-Expanded
PROFESÖR ÖZGÜR ÖZDEMİR →
Investigation of the effects of Theranekron and Sorafenib treatments on carcinogenesis, apoptosis and biochemical profile in hepatocellular carcinoma in rats.
Toxicology mechanisms and methods · 2024 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ BEYZA SUVARIKLI ALAN →
Makale Bilgileri
DergiToxicology Mechanisms and Methods
Yayın TarihiOcak 2024
Cilt / Sayfa34 · 750-760
Scopus ID2-s2.0-85189945101
Özet
This study aimed to investigate the effects of Tarantula cubensis alcohol extract (TCAE, Theranekron) and Sorafenib (S) treatments on carcinogenesis, apoptosis and biochemical profile of rats with experimentally induced hepatocellular carcinoma (HCC). In the presented study, 58 male rats were divided into 7 groups; Negative Control (NC, n = 6), NC + TCAE (NCT, n = 6), NC + Sorafenib (NCS, n = 6), Positive Control (PC, n = 10), Positive Control + TCAE (PCT, n = 10), Positive Control + Sorafenib (PCS, n = 10), Positive Control + TCAE + Sorafenib (PCTS, n = 10). The active ingredients Diethylnitrosamine (DEN, 120 mg/kg, single dose) and Nitrosomorpholine (NMOR, 50 ppm, 21 weeks orally) were used to induce HCC in rats. At the end of the experiment, the animals were euthanized under appropriate conditions and samples were collected for biochemical and pathological investigations. In the PC group, alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyl transpeptidase (GGT) levels were higher (p < 0.001) and urea levels were lower (p < 0.001) compared to all other groups. Treatment groups reorganized the relevant markers (ALT, AST, GGT, and urea). A significant increase was detected in Caspase-10, Caspase-3 and Granzyme-B (GrzB) (p < 0.001) in blood and Caspase-10 and GrzB (p < 0.05) in liver tissue in PCT, PCS and PCTS groups compared to the PC group. Histopathological examination revealed that the PC group showed cancer morphology, and the treatment groups caused a decrease in tumor incidence and size. Our current findings suggest that the mechanism of action of TCAE in HCC is through the NKs/CTLs-GrzB-Casp10-Casp3 signaling pathway and can be used in combination with chemotherapy drugs for the development of future drug designs.
Yazarlar (5)
1
Serdar Vanli
ORCID: 0000-0001-5811-9571
2
Firuze Kurtoǧlu
3
Beyza S. Alan
ORCID: 0000-0003-4698-9291
4
G. Akcakavak
5
O. Ozdemir
Anahtar Kelimeler
caspase-10
Caspase-3
Granzyme-B
hepatocellular carcinoma
Sorafenib
Theranekron
Kurumlar
Bozok Üniversitesi
Yozgat Turkey
Selçuk Üniversitesi
Selçuklu Turkey
T.C. Tarim ve Köyişleri Bakanliği
Antakya Turkey