Scopus
YÖKSİS DOI Eşleşti
SJR Q1
3′,4′-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia
Nutritional Neuroscience · Şubat 2017
YÖKSİS Kayıtları
3′,4′-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia
Nutritional Neuroscience · 2017 SCI
Prof. Dr. ABDULKERİM KASIM BALTACI →
YÖKSİS Kayıtları — ISSN Eşleşmesi
3′,4′-Dihydroxyflavonol attenuates spatial learning and memory impairments in global cerebral ischemia
2017 ISSN: 1028-415X SCI
Prof. Dr. ABDULKERİM KASIM BALTACI →
The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review
2024 ISSN: 1028-415X SCI Q2
Prof. Dr. RASİM MOĞULKOÇ →
Makale Bilgileri
Dergi
Nutritional Neuroscience
ISSN1028415X
Yayın TarihiŞubat 2017
Cilt / Sayfa20 · 119-126
Scopus ID2-s2.0-84978531959
Özet
Objectives: In the present study, effects of 3′,4′-dihydroxyflavonol (DiOHF) on anxiety-like behavior, and learning and memory were investigated in a model of transient global cerebral ischemia and reperfusion. Methods: The animals were assigned to sham-operated, ischemia, and two DiOHF-treated (10 mg/kg i.p.) groups. DiOHF was administered at 1 hour before and immediately after the ischemia. Male rats were subjected to bilateral common carotid artery occlusion to induce acute cerebral ischemia for 20 minutes, followed by reperfusion for 7 days. The openfield, elevated plus maze (EPM), and Morris water maze tests were used to evaluate the effects of DiOHF treatment on ischemia-induced locomotor activity, anxiety-like behavior, and spatial and recognition memory impairments, respectively. Results: In the open field test, locomotor activity in the ischemic rats was not altered 6 days after the ischemia, nor was anxiety-like behavior, which was evaluated with the EPM (P > 0.05). In the water-maze test, cerebral ischemia significantly decreased the exploration time in the target quadrant, and the platform crossing counts were lower (P < 0.05) in the probe trial test; this memory impairment was significantly improved by DiOHF applied 1 hour before and immediately after ischemia (P < 0.05). Discussion: All together, these findings suggest that DiOHF reverses spatial learning and memory deficits resulting from transient global ischemia but has no significant effect on anxiety-like behavior.
Yazarlar (6)
1
Mehmet Öz
2
Enver Ahmet Demir
3
Merve Caliskan
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci
6
Kismet Esra Nurullahoglu-Atalik
Anahtar Kelimeler
Anxiety-like behavior
DiOHF
Learning and memory
Stroke
Kurumlar
Necmettin Erbakan Üniversitesi
Meram Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Nutritional Neuroscience
Q1
SJR Skoru0,970
H-Index85
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Medicine (miscellaneous) (Q1)
Neuroscience (miscellaneous) (Q2)
Nutrition and Dietetics (Q2)
Metrikler
17
Atıf
6
Yazar
4
Anahtar Kelime