Scopus
Zinc Metabolism and Metallothioneins
Biological Trace Element Research · Mayıs 2018
Makale Bilgileri
DergiBiological Trace Element Research
Yayın TarihiMayıs 2018
Cilt / Sayfa183 · 22-31
Scopus ID2-s2.0-85028536131
Özet
Among the trace elements, zinc is one of the most used elements in biological systems. Zinc is found in the structure of more than 2700 enzymes, including hydrolases, transferases, oxyreductases, ligases, isomerases, and lyases. Not surprisingly, it is present in almost all body cells. Preserving the stability and integrity of biological membranes and ion channels, zinc is also an intracellular regulator and provides structural support to proteins during molecular interactions. It acts as a structural element in nucleic acids or other gene-regulating proteins. Metallothioneins, the low molecular weight protein family rich in cysteine groups, are involved significantly in numerous physiological and pathological processes including particularly oxidative stress. A critical role of metallothioneins (MT) is to bind zinc with high affinity and to serve as an intracellular zinc reservoir. By releasing free intracellular zinc when needed, MTs mediate the unique physiological roles of zinc. MT expression is induced by zinc elevation, and thus, zinc homeostasis is maintained. That MT mediates the effects of zinc, besides having strong radical scavenging effects, points to the critical part it plays in oxidative stress. The present review aims to give information on metallothioneins, which have critical importance in the metabolism and molecular pathways of zinc.
Yazarlar (3)
1
Abdulkerim Kasim Baltaci
2
Kemal Yuce
3
Rasim Mogulkoc
Anahtar Kelimeler
Metabolism
Metallothioneins
Physiological functions
Zinc
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
124
Atıf
3
Yazar
4
Anahtar Kelime