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Melatonin protects retinal tissue damage in streptozotocin-induced aged rats

Archives of Gerontology and Geriatrics · Eylül 2023

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YÖKSİS Kayıtları
Melatonin protects retinal tissue damage in streptozotocin-induced aged rats.
Archives of gerontology and geriatrics · 2023 SSCI
Prof. Dr. RASİM MOĞULKOÇ →
Melatonin protects retinal tissue damage in Streptozotocin-induced aged rats.
ARCHIVES OF GERONTOLOGY AND GERIATRICS · 2023 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
YÖKSİS ISSN Eşleşmesi

Bu dergide (ISSN eşleşmesi) kurumun 8 kaydı bulundu.

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Reproductive history socioeconomic status and disability in the women aged 65 years or older in Turkey
2010 ISSN: 0167-4943 SCI-Expanded 3 atıf
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Predictors of clock drawing test CDT performance in elderly patients attending an internal medicine outpatient clinic A pilot study on sun exposure and physical activity
2011 ISSN: 01674943 SCI
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The effect of physical activity on depressive symptoms and quality of life among elderly nursing home residents: Randomized controlled trial
2017 ISSN: 0167-4943 SSCI
Prof. Dr. NESLİHAN LÖK →
The effect of physical activity on depressive symptoms and quality of life among elderly nursing home residents: Randomized controlled trial
2017 ISSN: 0167-4943 SCI
Prof. Dr. NESLİHAN LÖK →
Melatonin protects retinal tissue damage in Streptozotocin-induced aged rats.
2023 ISSN: 0167-4943 SCI-Expanded Q2
Prof. Dr. ABDULKERİM KASIM BALTACI →
Melatonin protects retinal tissue damage in streptozotocin-induced aged rats.
2023 ISSN: 0167-4943 SSCI Q2
Prof. Dr. RASİM MOĞULKOÇ →
Pilot testing of the "First You Should Get Stronger" program among caregivers of older adults with dementia
2017 ISSN: 0167-4943 SCI Q3
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The effect of physical activity on depressive symptoms and quality of life among elderly nursing home residents: Randomized controlled trial
2017 ISSN: 0167-4943 SCI Q3
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Makale Bilgileri

Dergi Archives of Gerontology and Geriatrics
ISSN01674943
Yayın TarihiEylül 2023
Cilt / Sayfa112
DOI10.1016/j.archger.2023.105035
Scopus ID2-s2.0-85152524452
Özet Objectives: The aim of this study was to investigate how melatonin administration affects retinal oxidative damage and retinal SIRT1 gene activation in diabetic elderly female rat model. Methods: 16-months-old female rats were used in the study. A total of 24 rats were divided into 4 groups in equal numbers: Group 1. Control, Group 2. Control + Melatonin, Group 3. Diabetes, Group 4. Diabetes + Melatonin. In group 3 and 4 rats, diabetes was induced by intraperitoneal (IP) injection of streptozotocin. Groups 2 and 4 were given ip melatonin for 4 weeks. SIRT-1 gene expression was determined by PCR method and GSH and MDA levels by ELISA in retinal tissue samples taken from animals sacrificed under general anesthesia. Results: In our study, the highest retinal SIRT1 expression values were obtained in the diabetes + melatonin (G4) group. The retinal SIRT1 expression values of the diabetes group (G3) were lower than group 4 and higher than the general control (G1) and control + melatonin (G2) groups. Again in our study, the highest retinal MDA values were obtained in the diabetes group (G3). The highest retinal GSH values were obtained in the Diabetes + melatonin group (G4). Conclusion: The results of our study showed that melatonin supplementation has a protective effect on retinal tissue in a diabetic elderly female rat model. This protective effect of melatonin supplementation occurs by increasing both retinal antioxidant activity and retinal SIRT1 gene expression.

Yazarlar (5)

1
Adem Atacak
2
Saltuk Bugra Baltaci
3
Nilufer Akgun-Unal
4
Rasim Mogulkoc
5
Abdulkerim Kasim Baltaci

Anahtar Kelimeler

Diabetes Melatonin Oxidative stres Retinal tissue SIRT1

Kurumlar

Ondokuz Mayis University, Medical School
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Archives of Gerontology and Geriatrics
Q1
SJR Skoru1,321
H-Index108
YayıncıElsevier Ireland Ltd
ÜlkeIreland
Geriatrics and Gerontology (Q1)
Gerontology (Q1)
Health (social science) (Q1)
Aging (Q2)
Dergi sayfasına git

Metrikler

5
Atıf
5
Yazar
5
Anahtar Kelime

Sistemimizdeki Yazarlar

AB
ABDULKERİM KASIM BALTACI
Prof. Dr.

Hızlı Erişim

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