Scopus
YÖKSİS DOI Eşleşti
SJR Q2
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
British Poultry Science · Ocak 2022
YÖKSİS Kayıtları
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
BRITISH POULTRY SCIENCE · 2022 SCI-Expanded
Prof. Dr. MUSTAFA ORTATATLI →
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
British Poultry Science · 2022 SCI
Prof. Dr. ÖZGÜR ÖZDEMİR →
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
British Poultry Science · 2021 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
BRITISH POULTRY SCIENCE · 2022 SCI-Expanded
Prof. Dr. FATİH HATİPOĞLU →
The ameliorative effects of Nigella sativa, thymoquinone, and bentonite against aflatoxicosis in broilers via AFAR and Nrf2 signalling pathways, and down-regulation of caspase-3
British Poultry Science · 2022 SCI
Doç. Dr. MEHMET BURAK ATEŞ →
YÖKSİS Kayıtları — ISSN Eşleşmesi
The effect of dietary calcium concentration and particle size on performance eggshell quality bone mechanical properties and tibia mineral contents in moulted laying hens
2011 ISSN: 0007-1668 SCI
Prof. Dr. ALPÖNDER YILDIZ →
Embryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999
2000 ISSN: 0007-1668 SSCI 25 atıf
Prof. Dr. HASAN HÜSEYİN DÖNMEZ →
Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers
2000 ISSN: 0007-1668 SSCI 31 atıf
Prof. Dr. HASAN HÜSEYİN DÖNMEZ →
Embryotoxicity assay of aflatoxin produced by Aspergillusparasiticus NRRL 2999
2000 ISSN: 0007-1668 SSCI
Prof. Dr. EMRAH SUR →
Effects of aflatoxin B1 on the development of the bursaof Fabricius and blood lymphocyte acid phosphatase ofthe chicken
2003 ISSN: 0007-1668 SSCI
Prof. Dr. EMRAH SUR →
Effects of continuous supplementations of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens
2000 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. BÜNYAMİN TRAŞ →
Effects of dietary boron supplementation on some biochemical parameters peripheral blood lymphocytes splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol vitamin D content
2005 ISSN: 0007-1668 SCI
Prof. Dr. FİRUZE KURTOĞLU →
Embryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999 title
2000 ISSN: 0007-1668 SSCI
Prof. Dr. İLHAMİ ÇELİK →
Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers
2000 ISSN: 0007-1668 SSCI
Prof. Dr. İLHAMİ ÇELİK →
Bioavailability and pharmacokinetic profile of levofloxacin following intravenous intramuscular and oral administration in turkeys
2014 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. KAMİL ÜNEY →
Effects of polyvinylpolypyrrolidone synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis
1998 ISSN: 0007-1668 SCI 134 atıf
Prof. Dr. TUFAN KEÇECİ →
Effects of dietary boron supplementation on some biochemical parameters peripheral blood lymphocytes splenic plasma cells and bone characteristics of broiler chicks given diets with adequate or inadequate cholecalciferol vitamin D sub 3 sub content title
2005 ISSN: 0007-1668 SCI 55 atıf
Prof. Dr. TUFAN KEÇECİ →
Evaluation of the detoxifying effect of yeast glucomannan on aflatoxicosis in broilers as assessed by gross examination and histopathology
2005 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
The effects of withdrawal of vitamin and trace mineral supplements from layer diets on egg yield and trace mineral composition
2001 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. NURETTİN GÜLŞEN →
Effects of continuous supplementations of ascorbic acid aspirin vitamin E and selenium on some haematological parameters and serumsuperoxide dismutase level in broiler chickens
2000 ISSN: 0007-1668 SCI-Expanded 24 atıf
Prof. Dr. MUAMMER ELMAS →
The effects of different dietary copper on production performance and cholesterol concentrations of egg in laying hens
2004 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. TAHİR BALEVİ →
Effects of Echinacea extract on the performance antibody titres andintestinal histology of layer chicks
2010 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. TAHİR BALEVİ →
Effect of clinoptilolite on performance of broiler chickens during experimental aflatoxicosis
2000 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Emryotoxicity assay of aflatoxin produced by Aspergillus parasiticus NRRL 2999
2000 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Effects of polyvinyl polypyrrolidone synthetic zeolite and bentonite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis
1998 ISSN: 0007-1668 SCI-Expanded
Prof. Dr. HALİS UĞUZ →
Makale Bilgileri
Dergi
British Poultry Science
ISSN00071668
Yayın TarihiOcak 2022
Cilt / Sayfa63 · 332-339
Scopus ID2-s2.0-85121124245
Özet
1. Aflatoxins (AFs) are metabolites which especially have toxic effects on proteins, and are detoxified by the aflatoxin-B1 aldehyde reductase (AFAR) pathway. In this pathway, the aldo-keto reductase family 7, member A2 (AKR7A2) enzyme, which is controlled by nucleic-related erythroid factor 2 (Nrf2), plays an active role. However, data on the efficacy of this critical pathway in broilers is limited. 2. The aim of the following study was to investigate the changes in the expression levels of AKR7A2, Nrf2, and caspase-3, and the effects of Nigella sativa seeds (NS), thymoquinone (TMQ), and bentonite (BNT) in broilers exposed to AFs. 3. One-hundred broilers were divided into ten groups (control (CNT); AF; NS; TMQ; BNT; AF+TMQ; AF+NS; AF+BNT; AF+BNT+NS; AF+BNT+TMQ) and fed for 28 d. AF, TMQ, NS and BNT were added to diets at levels of 2 mg/kg, 300 mg/kg, 50 g/kg and 10 g/kg respectively. 4. The addition of AF to the diet decreased AKR7A2 and Nrf2 levels dramatically, but increased caspase-3 (P < 0.01). TMQ, NS and BNT additions to the diet eliminated all negative effects caused by AF (P < 0.01); and AKR7A2 and Nrf2 were further raised in TMQ and NS groups when compared to the control group. TMQ and NS showed a positive effect on detoxification parameters when given together with BNT. 5. Supplementation with NS and TMQ enhanced AF detoxification via the AFAR pathway, by increasing AKR7A2 and Nrf2 levels, in addition to reducing hepatocyte apoptosis.
Yazarlar (7)
1
Mehmet Burak Ates
ORCID: 0000-0003-1297-426X
2
M. Ortatatli
3
H. Oǧuz
4
O. Ozdemir
5
Funda Terzi
ORCID: 0000-0002-6184-5408
6
Mustafa Kemal Çiftçi
7
Fatih Hatipoglu
Anahtar Kelimeler
AKR7A2
apoptosis
black cumin
liver
Mycotoxin
Nrf2
Kurumlar
İstanbul Gelişim Üniversitesi
Istanbul Turkey
Kastamonu University
Kastamonu Turkey
Kyrgyz-Turkish Manas University
Bishkek Kyrgyzstan
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
British Poultry Science
Q2
SJR Skoru0,383
H-Index113
YayıncıTaylor and Francis Ltd.
ÜlkeUnited Kingdom
Animal Science and Zoology (Q2)
Food Science (Q3)
Medicine (miscellaneous) (Q3)
Metrikler
18
Atıf
7
Yazar
6
Anahtar Kelime