Scopus
YÖKSİS Eşleşti
Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade
Acta Veterinaria Hungarica · Eylül 2017
YÖKSİS Kayıtları
Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade
Acta Veterinaria Hungarica · 2017 SCI
DOÇENT HASAN ALKAN →
Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade
Acta Veterinaria Hungarica · 2017 SCI-Expanded
DOÇENT KÜBRA KARAKAŞ ALKAN →
Makale Bilgileri
DergiActa Veterinaria Hungarica
Yayın TarihiEylül 2017
Cilt / Sayfa65 · 382-393
Scopus ID2-s2.0-85030548485
Özet
The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent non-neoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
Yazarlar (7)
1
Elvan Anadol
2
Atiye Seda Yar Saglam
3
Nilgun Gultiken
4
Kubra Karakas-Alkan
ORCID: 0000-0001-9177-9299
5
Eray Alcigir
6
Hasan Alkan
ORCID: 0000-0001-8332-5334
7
Halit Kanca
Anahtar Kelimeler
Canine mammary tumour
COX-2
Gene expression
INOS
VEGF
Kurumlar
Ankara Üniversitesi
Ankara Turkey
Gazi Üniversitesi
Ankara Turkey
Ondokuz Mayis Üniversitesi
Samsun Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
14
Atıf
7
Yazar
5
Anahtar Kelime