Scopus
YÖKSİS Eşleşti
Dynamic contrast-enhanced magnetic resonance imaging for evaluating early response to radiosurgery in patients with vestibular schwannoma
Japanese Journal of Radiology · Temmuz 2022
YÖKSİS Kayıtları
Dynamic contrast-enhanced magnetic resonance imaging for evaluating early response to radiosurgery in patients with vestibular schwannoma
Japanese Journal of Radiology · 2022 SCI-Expanded
DOÇENT HALİL ÖZER →
Makale Bilgileri
DergiJapanese Journal of Radiology
Yayın TarihiTemmuz 2022
Cilt / Sayfa40 · 678-688
Scopus ID2-s2.0-85123117183
Özet
Purpose: This study aimed to use dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to evaluate early treatment response in vestibular schwannoma (VS) patients after radiosurgery. Methods: Twenty-four VS patients who underwent gamma knife radiosurgery were prospectively followed up for at least four years. DCE-MRI sequences, in addition to standard MRI protocol, were obtained prior to radiosurgery, at 3 and 6 months. Conventionally, treatment responses based on tumor volume changes were classified as regression or stable (RS), transient tumor enlargement (TTE), and continuous tumor enlargement (CTE). DCE-MRI parameters, such as Ktrans, Kep and Ve, were compared according to follow-up periods and between groups. The diagnostic performance was tested using receiver operating characteristic (ROC) curves. Results: Changes in tumor volume were as follows at the last 48 months of follow-up: RS in 11 patients (45.8%), TTE in 10 patients (41.7%), and CTE in three patients (12.5%). The median time required to distinguish TTE from CTE using conventional MRI was 12 months (range 9–18). The Ktrans and Ve were significantly decreased in patients with RS and TTE at 3 and 6 months, but did not differ significantly in patients with CTE. There were no significant differences in Ktrans and Ve between patients with RS and TTE at 3 and 6 months. Both Ktrans and Ve demonstrated high diagnostic performance in evaluating early treatment response to radiosurgery in patients with VS. Conclusion: DCE-MRI may aid in the monitoring and early prediction of treatment response in patients with VS following radiosurgery.
Yazarlar (6)
1
Halil Özer
ORCID: 0000-0003-1141-1094
2
Merve Yazol
ORCID: 0000-0003-1437-8998
3
Nesrin Erdoğan
ORCID: 0000-0002-3319-0301
4
Ömer Hakan Emmez
ORCID: 0000-0002-3290-179X
5
Gökhan Kurt
ORCID: 0000-0002-2773-056X
6
Ali Yusuf Öner
ORCID: 0000-0003-1123-6521
Anahtar Kelimeler
Magnetic resonance imaging
Radiosurgery
Vestibular schwannoma
Kurumlar
Gazi University, Faculty of Medicine
Ankara Turkey
Metrikler
3
Atıf
6
Yazar
3
Anahtar Kelime