Scopus
YÖKSİS DOI Eşleşti
SJR Q2
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
Molecular Biology Reports · Temmuz 2021
YÖKSİS Kayıtları
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
Molecular Biology Reports · 2021 SCI-Expanded
Doç. Dr. MERİH ÖNAL →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
Molecular Biology Reports · 2021 SCI-Expanded
Doç. Dr. ÇAĞDAŞ ELSÜRER →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
Molecular Biology Reports · 2021 SCI-Expanded
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
Molecular Biology Reports · 2021 SCI-Expanded
Prof. Dr. METE KAAN BOZKURT →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Decision tree-based evaluation of IGF-1 and CAST gene polymorphisms associated with morphometric traits in sheep
2026 ISSN: 0301-4851 SCI Q3
Arş. Gör. AYŞE NUR TANIŞ →
Glutathione S-transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 IM: Index Medicus
Prof. Dr. TÜLÜN ÇORA →
In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium
2019 ISSN: 0301-4851 SCI
Prof. Dr. NURANİYE ERUYGUR →
NF‑ĸβ upregulates ADAMTS5 expression by direct binding after TNF‑α
treatment in OUMS‑27 chondrosarcoma cell line 2020 Jun;47(6):4215-4223
2020 ISSN: 0301-4851 SSCI
Prof. Dr. TÜLÜN ÇORA →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Arş. Gör. FATMA GÖKTÜRK →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. MERİH ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge
between circadian rhythm and glucose metabolism, in a Turkish
population
2021 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Relationship of endoplasmic reticulum stress with the etiopathogenesis of chronic tonsillitis and tonsillar hypertrophy in pediatric patients: a prospective, parallel-group study
2021 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. İBRAHİM ÖZKAN ÖNAL →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
2021 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUSLU KAZIM KÖREZ →
A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study
2022 ISSN: 0301-4851 SCI-Expanded Q4
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Glutathione S transferase M1 and T1 genotypes and myocardial infarction
2013 ISSN: 0301-4851 SCI
Prof. Dr. HASAN ACAR →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. BAHADIR ÖZTÜRK →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi DUYGU DURSUNOĞLU →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Doç. Dr. DUDU ERKOÇ KAYA →
Juglone-ascorbate treatment enhances reactive oxygen species mediated mitochondrial apoptosis in pancreatic cancer
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. ESMA MENEVŞE →
Investigation the effects of bee venom and H-dental-derived mesenchymal stem cells on non-small cell lung cancer cells (A549)
2024 ISSN: 0301-4851 SCI-Expanded Q3
Prof. Dr. HÜSAMETTİN VATANSEV →
Investigation of the effects of gabapentin on high glucose-induced neurotoxicity and genotoxicity in an in vitro model of diabetic neuropathy and in silico molecular docking analysis
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi BATUHAN BİLGİN →
Comparison of the neuroprotective effects of gossypin on cisplatin-induced neurotoxicity in vitro and in vivo
2025 ISSN: 0301-4851 SCI-Expanded Q3
Dr. Öğr. Üyesi MUHAMMED YAYLA →
Makale Bilgileri
ISSN03014851
Yayın TarihiTemmuz 2021
Cilt / Sayfa48 · 5579-5586
Scopus ID2-s2.0-85112400281
Özet
Objectives: Tonsil tissue is a very important component of the human immunity system, contributing to the functioning of the cellular and humoral defence system, especially in childhood. The endoplasmic reticulum (ER) is an organelle that has a very important function in the balanced functioning of cells, in which the accumulation of a cellular protein called ER stress occurs in case of dysfunction. ER stress influences the pathogenesis of many diseases and immune system functions. We aimed to investigate the relation between the diseases of tonsil tissue and ER stress response to elucidate the mechanisms of diseases related with the immune system. Methods: A prospective study was conducted in 46 children aged between 2 and 16 years who underwent tonsillectomy for chronic tonsillitis or tonsillar hypertrophy. Tonsil tissue was separated into two groups according to their size and evaluated in terms of ER stress markers and apoptosis markers by Real-time PCR and Western blot analysis. Results: The ΔCT levels of ER stress markers (ATF4, ATF6, CHOP, GRP78, EIF2AK3, ERN1, GRP94) were greater in children with chronic tonsillitis (p < 0.005). In contrast, the tonsillar hypertrophy group had greater ΔCT levels of apoptosis markers (BAX, BCL-2) according to the Real-time PCR method (p < 0.005). According to the Western blot analysis, the normalized levels of ATF4, ATF6, CHOP, GRP78, and ERN1 genes were found greater in the chronic tonsillitis group than the tonsillar hypertrophy group. There was no difference between the two groups in terms of normalized BCL-2 and BAX levels by Western blot analysis. Conclusion: This is the first study in the literature investigating the effect of the ER stress pathway on the etiopathogenesis of tonsil diseases. It was concluded that the ER stress pathway plays a role in the etiopathogenesis of chronic tonsillitis. Investigating the relationship between ER stress and structures such as the tonsil tissue that make up the immune system can help create new treatment strategies. Clinical Trial Registration: Trial Registration ClinicalTrials.gov Identifier: NCT04653376.
Yazarlar (7)
1
Merih Onal
ORCID: 0000-0003-0591-8411
2
Nadir Koçak
ORCID: 0000-0002-1104-1292
3
Fahrettin Duymus
4
Mete Kaan Bozkurt
ORCID: 0000-0002-3153-3294
5
Çağdaş Elsürer
ORCID: 0000-0001-9804-7023
6
O. Erdur
7
Ozkan Onal
ORCID: 0000-0002-5574-1901
Anahtar Kelimeler
Apoptosis
Children
Endoplasmic reticulum stress
Genetics
Palatine tonsil
Tonsillitis
Kurumlar
Cleveland Clinic Foundation
Cleveland United States
Selçuk Tip Fakültesi
Konya Turkey
Scimago Dergi (ISSN Eşleşmesi)
Molecular Biology Reports
Q2
SJR Skoru0,743
H-Index103
YayıncıSpringer Science and Business Media B.V.
ÜlkeNetherlands
Genetics (Q2)
Medicine (miscellaneous) (Q2)
Molecular Biology (Q3)
Metrikler
6
Atıf
7
Yazar
6
Anahtar Kelime