Scopus
YÖKSİS Eşleşti
Comparative pharmacokinetics of enrofloxacin and tissue concentrations of parent drug and ciprofloxacin after intramuscular administrations of free and liposome-encapsulated enrofloxacin in rabbits
Journal of Veterinary Medicine, Series B · Aralık 2002
YÖKSİS Kayıtları
Comparative pharmacokinetics of enrofloxacin and tissue concentrationsof parent drug and ciprofloxacin after intramuscular administrations offree and liposome encapsulated enrofloxacin in rabbits
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES ANDVETERINARY PUBLIC HEALTH · 2002 SCI-Expanded 39 atıf
PROFESÖR AHMET LEVENT BAŞ →
Comparative pharmacokinetics of enrofloxacin and tissue concentrationsof parent drug and ciprofloxacin after intramuscular administrations offree and liposome encapsulated enrofloxacin in rabbits
JOURNAL OF VETERINARY MEDICINE SERIES B-INFECTIOUS DISEASES ANDVETERINARY PUBLIC HEALTH · 2002 SCI-Expanded 39 atıf
PROFESÖR MUAMMER ELMAS →
Comparative Pharmacokinetics of Enrofloxacin and Tissue Concentrations of Parent Drug and Ciprofloxacin after Intramuscular Administrations of Free and Liposome Encapsulated Enrofloxacin in Rabbits
Journal of Veterinary Medicine Series B · 2002 SSCI 10 atıf
PROFESÖR AHMET LEVENT BAŞ →
Comparative Pharmacokinetics of Enrofloxacin and Tissue Concentrations of Parent Drug and Ciprofloxacin after Intramuscular Administrations of Free and Liposome Encapsulated Enrofloxacin in Rabbits
Journal of Veterinary Medicine Series B · 2002 SSCI
PROFESÖR AHMET LEVENT BAŞ →
Makale Bilgileri
DergiJournal of Veterinary Medicine, Series B
Yayın TarihiAralık 2002
Cilt / Sayfa49 · 507-512
Scopus ID2-s2.0-0036942528
Özet
Pharmacokinetic properties and tissue concentrations of enrofloxacin and ciprofloxacin were compared after intramuscular (i.m.) administrations of free and liposome-encapsulated enrofloxacin at the dose of 5 mg/kg body weight (bw). Twelve healthy adult New Zealand white rabbits were used in the experiment. Blood samples were obtained at 10, 20, 40, 60 and 90 min and 2, 4, 6, 8 and 12 h and tissue samples were collected 24 h after injection. Concentrations of drugs in serum were determined by high-performance liquid chromatography. Pharmacokinetics were best described by a two-compartment open model. Results indicated that absorption rate was slow, peak concentration was higher (P < 0.05), and the time to peak concentration (tmax ≅ 1.5 h) was significantly longer (P < 0.05) for liposome-encapsulated enrofloxacin (LEE) when compared with free enrofloxacin. Values of elimination half-life (t1/2β = 12.9 h) and mean residence time (MRT = 17.6 h) of liposome-encapsulated enrofloxacin were longer (P < 0.05) and total clearance (Cl = 0.43 l/h/kg) was lower than those of free form. Moreover, the distribution volume at steady-state (Vd(ss) = 14.4 l/kg) of enrofloxacin administered encapsulated into liposomes was significantly higher (P < 0.05) than that of free enrofloxacin (FE). The tissue levels of enrofloxacin and ciprofloxacin after LEE injection were not different (P > 0.05) from FE. In conclusion, the result of present study suggest that LEE may be a beneficial and valuable formulation in the treatment of infectious diseases caused by sensitive pathogens in animals, providing sustained drug release from injection side and prolonged therapeutic serum concentrations after i.m. administration.
Yazarlar (6)
1
M. Elmas
2
E. Yazar
3
A. L. Baş
4
B. Traş
5
M. Bayezit
6
Kursad Yapar
Kurumlar
Kafkas Üniversitesi, Veteriner Fakültesi
Kars Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
16
Atıf
6
Yazar