Scopus
YÖKSİS DOI Eşleşti
SJR Q3
Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice
Acta Veterinaria Hungarica · Mart 2010
YÖKSİS Kayıtları
EFFECTS OF TYLOSIN ON SERUM CYTOKINE LEVELS IN HEALTHY ANDLIPOPOLYSACCHARIDE TREATED MICE
ACTA VETERINARIA HUNGARICA · 2010 SCI-Expanded 18 atıf
Prof. Dr. MUAMMER ELMAS →
Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide treated mice
Acta Veterinaria Hungarica · 2010 SCI-Expanded 9 atıf
Prof. Dr. KAMİL ÜNEY →
Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide treated mice
Acta Veterinaria Hungarica · 2010 SCI
Prof. Dr. AYŞE ER →
Effects of tylosin on serum cytokine levels in healthy and lipopolysaccharide-treated mice
Acta Veterinaria Hungarica · 2010 SCI-Expanded
Prof. Dr. ENVER YAZAR →
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title Plasma disposition of cefoperazone after single intravenous and intramuscular administrations in camels ( iCamelus dromedarius/i )/title
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Effect of pentoxifylline on endotoxin-induced haemostatic, disturbances in rabbits
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Changes In Novel Gastrointestinal And Renal Injury Markers In The Blood Plasma Of Sheep Following Increasing Intravenous Doses Of Tolfenamic Acid
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Heart-type fatty acid-binding protein (H-FABP), pentraxin-3 (PTX-3) and thrombomodulin in bovine traumatic pericarditis
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Makale Bilgileri
ISSN02366290
Yayın TarihiMart 2010
Cilt / Sayfa58 · 75-81
Scopus ID2-s2.0-77249179775
Özet
The effects of different doses of tylosin on serum cytokine concentrations were investigated in healthy and lipopolysaccharide-treated mice. The mice were divided into seven groups. Lipopolysaccharide (LPS) was injected into the positive control group. The other six groups received three different tylosin doses concurrently without or with LPS: 10 mg/kg, 100 mg/kg, 500 mg/kg, 10 mg/kg + LPS, 100 mg/kg + LPS and 500 mg/kg + LPS. After treatment, serum samples were collected at 0, 1, 2, 3, 6, 12 and 24 hours. Serum tumour necrosis factor α (TNFα), interleukin 1β (IL1β) and IL10 levels were determined by enzyme-linked immunosorbent assay (ELISA). Tylosin doses of 10 and 100 mg/kg induced no cytokine production in the healthy mice. Tylosin at 500 mg/kg had no effect on TNFα or IL1β production, but it induced IL10 production in healthy mice. All doses of tylosin reduced the elevated TNFα and IL1β in LPS-treated mice but increased their IL10 levels. In conclusion, these data suggest that tylosin has an immunomodulatory effect at the dose recommended for use against infection. © 2010 Akadémiai Kiadó, Budapest.
Yazarlar (6)
1
A. Er
2
E. Yazar
3
Kamil Üney
ORCID: 0000-0002-8674-4873
4
M. Elmas
5
Feray Altan
6
Gul Cetin
Anahtar Kelimeler
IL10
IL1β
LPS
TNFα
Tylosin
Kurumlar
Dicle Üniversitesi
Diyarbakir Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Acta Veterinaria Hungarica
Q3
SJR Skoru0,281
H-Index42
YayıncıAkademiai Kiado ZRt.
ÜlkeHungary
Veterinary (miscellaneous) (Q3)
Metrikler
12
Atıf
6
Yazar
5
Anahtar Kelime