Scopus
YÖKSİS Eşleşti
Effects of treatment with coenzyme Q <inf>10</inf> on exercised rat aorta
Acta Physiologica Hungarica · Mart 2012
YÖKSİS Kayıtları
Effects of treatment with coenzyme Q 10 on exercised rat aorta
ACTA PHYSIOLOGICA HUNGARICA · 2012 SSCI
PROFESÖR NİLSEL OKUDAN →
Effects of treatment with coenzyme Q10 on exercised rat aorta
Acta Physiologica Hungarica · 2012 SCI-Expanded
PROFESÖR MUAZ BELVİRANLI →
Makale Bilgileri
DergiActa Physiologica Hungarica
Yayın TarihiMart 2012
Cilt / Sayfa99 · 40-50
Scopus ID2-s2.0-84858987408
Özet
In this study, the effect of long-term supplementation of coenzyme Q 10 (CoQ 10) on the responses of swim-trained rat aorta was investigated. Twenty-four adult male Wistar rats were divided into four groups: untrained, trained, untrained+CoQ 10, and trained+CoQ 10 group. In the trained groups rats swam for 60 min/day, five days/week for six weeks. The CoQ 10 supplements were administered by intraperitoneal injection at a daily dose of 10 mg·kg -1 of body weight five days/week for six weeks. Swimming of the rats was performed in a container containing tap water. Rats were sacrificed and thoracic aortas were removed for ex vivo analysis after the last swimming session. The aortas were cut into rings 2.5 mm in length. Concentration-response curves for phenylephrine (PHE, 10 -9-3×10 -4 M) and potassium chloride (KCl, 5-100 mM) were isometrically recorded. The sensitivity and maximal responses to PHE and KCl of aortic rings obtained from trained rats were lower than those of untrained rats. CoQ 10 supplementation decreased the responses to both vasoconstrictors in untrained and especially in trained groups. Although neither CoQ 10 nor training did affect malondialdehyde (MDA) and protein carbonyl (PC) levels, creatine kinase (CK) activity decreased and superoxide dismutase (SOD) activity increased only with exercise training. Glutathione (GSH) levels increased in CoQ 10 supplemented-untrained rats. In conclusion, our results suggest that CoQ 10 supplementation may have beneficial effects during exercise. © 2012 Akadémiai Kiadó, Budapest.
Yazarlar (7)
1
Nilsel Okudan
2
Kismet Esra Nurullahoglu-Atalik
3
Serkan Revan
4
Muaz Belviranli
5
Şükrü Serdar Balci
6
H. Gökbel
7
Hamdi Pepe
Anahtar Kelimeler
aorta
coenzyme Q10
contractions
exercise
Kurumlar
NEÜ Meram Medicine Faculty
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
5
Atıf
7
Yazar
4
Anahtar Kelime