Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · Eylül 2022
YÖKSİS Kayıtları
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Prof. Dr. ESMA MENEVŞE →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Prof. Dr. NİHAL ÇETİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
Journal of Drug Delivery Science and Technology · 2022 SCI-Expanded
Dr. Öğr. Üyesi CENGİZHAN CEYLAN →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Development and in vitro evaluation of temozolomide-loaded PLGA nanoparticles in a thermoreversible hydrogel system for local administration in glioblastoma multiforme
2020 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi SEMA ARISOY →
In-vivo evaluation of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers and mesenchymal stem cells in diabetic wound healing
2021 ISSN: 1773-2247 SSCI Q2
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and characterization of tissue scaffolds containing simvastatin loaded nanostructured lipid carriers for treatment of diabetic wounds
2017 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Formulation and in vitro evaluation of topical nanoemulsion and nanoemulsion-based gels containing daidzein
2019 ISSN: 1773-2247 SSCI
Dr. Öğr. Üyesi DİLARA ÖRGÜL →
Development and characterization of polymeric nanoparticles containing ondansetron hydrochloride as a hydrophilic drug
2022 ISSN: 1773-2247 SCI-Expanded Q2
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Arş. Gör. TAMER TEKİN →
Preparation, characterization and evaluation of liposomal-freeze dried anthocyanin-enriched Vaccinium arctostaphylos L. fruit extract incorporated into fast dissolving oral films
2022 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. YÜKSEL KAN →
Evaluation of burn wound healing activity of thermosensitive gel and PLGA
nanoparticle formulation of quercetin in Wistar albino rats
2022 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ZELİHA ESİN ÇELİK →
Preparation and evaluation of fast-dissolving albendazole sulfoxide and praziquantel-loaded polyvinylpyrrolidone nanofiber films by electrospinning
2024 ISSN: 1773-2247 SCI Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Multifunctional hernia repair biopatch: Development, characterization, in vitro and in vivo evaluation
2024 ISSN: 1773-2247 SCI-Expanded Q1
Prof. Dr. MEHMET TUZCU →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Dr. Öğr. Üyesi ŞEYMA TETİK RAMA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded
Prof. Dr. ABDULLAH SİVRİKAYA →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Arş. Gör. KÜBRA YILMAZ →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi HARUN YONAR →
Silver loaded functionalized calix [4]arene nanofibers and evaluation in burn wound healing
2024 ISSN: 1773-2247 SCI-Expanded Q1
Öğr. Gör. FATİH ÖZCAN →
Development of phytase targeted PLGA nanoparticles loaded with albendazole sulfoxide and praziquantel and evaluation of efficacy on the hydatid cysts
2025 ISSN: 1773-2247 SCI-Expanded Q1
Dr. Öğr. Üyesi YAKUP GÜLTEKİN →
Makale Bilgileri
ISSN17732247
Yayın TarihiEylül 2022
Cilt / Sayfa75
Scopus ID2-s2.0-85135784541
Özet
Modern burn treatments with gene therapy, stem cells and healing factors are highly cost and not always possible to access these treatments. For this reason, new effective treatment approaches should have easy accessibility. Recent studies have shown that quercetin, a flavonoid, has a wound-healing effect. However, quercetin has low water solubility and cannot uptake into cells sufficiently. To overcome these disadvantages quercetin nanoparticle and thermosensitive gel formulations appear to be potential alternatives. In this study, to compare the efficacy of quercetin-loaded PLGA nanoparticle with quercetin-loaded pluronic thermosensitive gel formulations, nanoparticle and thermosensitive gel formulations were developed, characterized and evaluated in the burn model. Biochemical analysis has been performed to investigate the effects of formulations on such as growth factors and some cytokines that are effective in wound healing process. Finally, histopathological analyzes has been performed to evaluate the presence and density of granulation tissue, inflammation and fibrosis. Encapsulation efficiency (EE) of nanoparticles was found 25 ± 5%. It is indicating that during the preparation of PLGA nanoparticles, there is more quercetin lost than preparation process of gel. Also quercetin release from PLGA nanoparticles is limited when compared with gel formulation of quercetin. PLGA nanoparticles and thermosensitive gel formulations are effective when compared with quercetin solution and Silverdin®. Considering the cost of PLGA polymer, EE and efficacy results it was concluded that pluronic thermosensitive gel formulations could be a cost-effective option for burn wound therapy.
Yazarlar (8)
1
Nihal Cetin
2
Esma Menevşe
3
Zeliha Esin Celik
4
Cengizhan Ceylan
ORCID: 0000-0003-4164-9212
5
Seyma Tetik Rama
6
Yakup Gultekin
7
Tamer Tekin
8
Adem Sahin
ORCID: 0000-0002-3996-2931
Anahtar Kelimeler
Burn wound therapy
Nanoparticle
PLGA
Plunoric
Quercetin
Thermosensitive gel
Kurumlar
Bilecik Şeyh Edebali Üniversitesi
Bilecik Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Journal of Drug Delivery Science and Technology
Q1
SJR Skoru0,817
H-Index89
YayıncıEditions de Sante
ÜlkeFrance
Pharmaceutical Science (Q1)
Metrikler
21
Atıf
8
Yazar
6
Anahtar Kelime