Scopus
YÖKSİS DOI Eşleşti
SJR Q1
Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone
Regulatory Toxicology and Pharmacology · Haziran 2016
YÖKSİS Kayıtları
Investigation of developmental toxicity and teratogenicity of cyclosporine A tacrolimus and their combinations with prednisolone
Regulatory Toxicology and Pharmacology · 2016 SCI
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of developmental toxicity and teratogenicity of cyclosporine A tacrolimus and their combinations with prednisolone
Regulatory Toxicology and Pharmacology · 2016 SCI
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone
Regulatory Toxicology and Pharmacology · 2016 SCI-Expanded
Prof. Dr. HASAN ACAR →
YÖKSİS Kayıtları — ISSN Eşleşmesi
Investigation of developmental toxicity and teratogenicity of cyclosporine A tacrolimus and their combinations with prednisolone
2016 ISSN: 02732300 SCI
Prof. Dr. ZELİHA FAZLIOĞULLARI →
Investigation of developmental toxicity and teratogenicity of cyclosporine A, tacrolimus and their combinations with prednisolone
2016 ISSN: 0273-2300 SCI-Expanded Q1
Prof. Dr. HASAN ACAR →
A Case of Relapsed Chronic Myeloid Leukemia Admitted with the Complaints of Paraplegia and Urinary Incontinence
2016 ISSN: 0273-2300 SciEP
Prof. Dr. HASAN ACAR →
Makale Bilgileri
ISSN02732300
Yayın TarihiHaziran 2016
Cilt / Sayfa77 · 213-222
Scopus ID2-s2.0-84961730814
Özet
In this study, it was aimed to investigate the toxic and teratogenic effects of cyclosporine A and tacrolimus and their combinations with prednisolone using an in vitro rat embryo culture technique. Cyclosporine A (4-40 μg/ml), tacrolimus (1-20 μg/ml) and combinations of these drugs with prednisolone (20 μg/ml) at different concentrations were tested. Cyclosporine A and its combination with prednisolone were determined to have toxic effects on embryonic growth after 10 μg/ml. When used alone, the lowest dose of tacrolimus had embryotoxic effects on the total morphological score and number of somites. It was determined that cyclosporine A caused hematoma at 4 μg/ml and higher doses, and tacrolimus especially at 20 μg/ml caused an open neural tube beside hematoma. It was observed that cyclosporine A at 40 μg/ml dose initiated apoptotic effects at a very low rate, prednisolone increased this effect, tacrolimus led to excessive apoptosis after 15 μg/ml, and this effect did not change with prednisolone supplement. We are of the opinion that the doses should be determined carefully when cyclosporine A and tacrolimus are required to be administered to pregnant women with prednisolone combination, as prednisolone increases the toxic effects of cyclosporine A, and increases teratogenic effects of tacrolimus.
Yazarlar (5)
1
Nadire Unver Dogan
2
Ismihan Ilknur Uysal
3
Zeliha Fazliogullari
ORCID: 0000-0002-5103-090X
4
Ahmet Kagan Karabulut
5
Hasan Acar
Anahtar Kelimeler
Apoptosis
Cyclosporine A
In vitro embryo culture
Prednisolone
Tacrolimus
Kurumlar
Selçuk Üniversitesi
Selçuklu Turkey
Scimago Dergi (ISSN Eşleşmesi)
Regulatory Toxicology and Pharmacology
Q1
SJR Skoru0,944
H-Index131
YayıncıAcademic Press Inc.
ÜlkeUnited States
Medicine (miscellaneous) (Q1)
Toxicology (Q2)
Metrikler
16
Atıf
5
Yazar
5
Anahtar Kelime