Scopus
YÖKSİS Eşleşti
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · Mayıs 2021
YÖKSİS Kayıtları
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · 2021 SCI-Expanded
ARAŞTIRMA GÖREVLİSİ FATMA GÖKTÜRK →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · 2021 SCI
PROFESÖR HİLAL ARIKOĞLU →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · 2021 SCI-Expanded
PROFESÖR SÜLEYMAN BALDANE →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · 2021 SCI-Expanded
DOKTOR ÖĞRETİM ÜYESİ MUSLU KAZIM KÖREZ →
Type 2 diabetes is associated with the MTNR1B gene, a genetic bridge between circadian rhythm and glucose metabolism, in a Turkish population
Molecular Biology Reports · 2021 SCI-Expanded
PROFESÖR HİLAL ARIKOĞLU →
Makale Bilgileri
DergiMolecular Biology Reports
Yayın TarihiMayıs 2021
Cilt / Sayfa48 · 4181-4189
Scopus ID2-s2.0-85107882676
Özet
Type 2 diabetes (T2D) is a complicated public health problem in Turkey as well as worldwide. Genome-wide approaches have been guiding in very challenging situations, such as the elucidation of genetic variations underlying complex diseases such as T2D. Despite intensive studies worldwide, few studies have determined the genetic susceptibility to T2D in Turkish populations. In this study, we investigated the effect of genes that are strongly associated with T2D in genome-wide association (GWA) studies, including MTNR1B, CDKAL1, THADA, ADAMTS9 and ENPP1, on T2D and its characteristic traits in a Turkish population. In 824 nonobese individuals (454 T2D patients and 370 healthy individuals), prominent variants of these GWA genes were genotyped by real-time PCR using the LightSNiP Genotyping Assay System. The SNP rs1387153 C/T, which is located 28 kb upstream of the MTNR1B gene, was significantly associated with T2D and fasting blood glucose levels (P < 0.05). The intronic SNP rs10830963 C/G in the MTNR1B gene was not associated with T2D, but it was associated with fasting blood glucose, HbA1C and LDL levels (P < 0.05). The other important GWA loci investigated in our study were not found to be associated with T2D or its traits. Only the SNP rs1044498 (A/C variation) in the ENPP1 gene was determined to be related to fasting blood glucose (P < 0.05). Our study suggests, consistent with the literature, that the MTNR1B locus, which has a prominent role in glucose regulation, is associated with T2D development by affecting blood glucose levels in our population.
Yazarlar (8)
1
Hilal Arikoglu
ORCID: 0000-0002-6600-6603
2
Dudu Erkoc-Kaya
ORCID: 0000-0003-0114-6602
3
Suleyman Hilmi Ipekci
ORCID: 0000-0003-4410-2212
4
Fatma Gokturk
5
Funda Iscioglu
6
M. K. Korez
ORCID: 0000-0001-9524-6115
7
Süleyman Baldane
8
Mustafa Sait Gonen
Anahtar Kelimeler
MTNR1B gene
Single nucleotide polymorphisms
Turkish population
Type 2 diabetes
Kurumlar
Ege Üniversitesi
Izmir Turkey
Hisar Intercontinental Hospital
Istanbul Turkey
İstanbul University-Cerrahpaşa Cerrahpaşa Faculty of Medicine
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
Metrikler
4
Atıf
8
Yazar
4
Anahtar Kelime