Scopus
YÖKSİS Eşleşti
Raised total methylated arginine load in patients with gout
Biomarkers in Medicine · Eylül 2022
YÖKSİS Kayıtları
Raised total methylated arginine load in patients with gout
Biomarkers in Medicine · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Raised total methylated arginine load in patients with gout
Biomarkers in Medicine · 2022 SCI-Expanded
PROFESÖR FATMA HÜMEYRA YERLİKAYA AYDEMİR →
Raised total methylated arginine load in patients with gout
Biomarkers in Medicine · 2022 SCI-Expanded
DOÇENT GÜLSÜM ABUŞOĞLU →
Raised total methylated arginine load in patients with gout
BIOMARKERS IN MEDICINE · 2022 SCI-Expanded
PROFESÖR ALİ ÜNLÜ →
Makale Bilgileri
DergiBiomarkers in Medicine
Yayın TarihiEylül 2022
Cilt / Sayfa16 · 993-1004
Scopus ID2-s2.0-85138126222
Özet
Aim: The aim of this study was to measure serum levels of methylarginine derivatives and related metabolites in patients with gout. Materials & methods: This study enrolled 100 patients with gout and 80 patients in the control group. Serum asymmetric dimethylarginine, symmetric dimethylarginine, L-N-monomethylarginine, arginine, homoarginine, citrulline and ornithine levels were measured with tandem mass spectrometry. Results: Serum ornithine, citrulline and total methylated arginine load levels were statistically significantly higher in patients with gout compared with the control group, while serum arginine and homoarginine levels and global arginine bioavailability ratio were statistically significantly lower. Conclusion: There may be an association between gout, methylarginine levels and hyperuricemia and increased risk of cardiovascular disease.
Yazarlar (8)
1
Duygu Eryavuz Onmaz
ORCID: 0000-0001-8564-1824
2
Dilek Tezcan
ORCID: 0000-0002-8295-9770
3
Sedat Abusoglu
ORCID: 0000-0002-2984-0527
4
Sema Yılmaz
ORCID: 0000-0003-4277-3880
5
Menekse Kuzu
ORCID: 0000-0002-7076-1695
6
Gulsum Abusoglu
7
Fatma H Yerlikaya
ORCID: 0000-0002-4107-5389
8
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
asymmetric dimethylarginine
endothelial dysfunction
gout disease
hyperuricemia
nitric oxide
Kurumlar
Biruni Üniversitesi
Istanbul Turkey
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
University of Health Sciences
Istanbul Turkey