Scopus
YÖKSİS Eşleşti
A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
Clinical Chemistry and Laboratory Medicine · Aralık 2014
YÖKSİS Kayıtları
A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
Clinical Chemistry and Laboratory Medicine (CCLM) · 2014 SSCI 2 atıf
PROFESÖR HÜSAMETTİN VATANSEV →
A multicenter nationwide reference intervals study for common biochemical analytes in Turkey using Abbott analyzers
Clinical Chemistry and Laboratory Medicine (CCLM) · 2014 SCI-Expanded 2 atıf
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiClinical Chemistry and Laboratory Medicine
Yayın TarihiAralık 2014
Cilt / Sayfa52 · 1823-1833
Scopus ID2-s2.0-84910130520
Özet
Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (≥400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and γ-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m2. Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.
Yazarlar (57)
1
Yesim Ozarda
2
Kiyoshi Ichihara
3
Diler Aslan
4
Hulya Aybek
5
Zeki Ari
6
Fatma Taneli
7
Canan Coker
8
Pinar Akan
9
Ali Riza Sisman
10
Onur Bahceci
11
Nurzen Sezgin
12
Meltem Demir
13
Gultekin Yucel
14
Halide Akbas
15
Sebahat Ozdem
16
Gurbuz Polat
17
Ayse Binnur Erbagci
18
Mustafa Orkmez
19
Nuriye Mete
20
Osman Evliyaoglu
21
Aysel Kiyici
22
Hüsamettin Vatansev
23
Bahadır Öztürk
24
Dogan Yucel
25
Damla Kayaalp
26
Kubra Dogan
27
Asli Pinar
28
Mehmet Gürbilek
29
Cigdem Damla Cetinkaya
30
Okhan Akin
31
Muhittin Serdar
32
Ismail Kurt
33
Selda Erdinc
34
Ozgur Kadicesme
35
Necip Ilhan
36
Dilek Sadak Atali
37
Ebubekir Bakan
38
Harun Polat
39
Tevfik Noyan
40
Murat Can
41
Abdulkerim Bedir
42
Ali Okuyucu
43
Orhan Deger
44
Suret Agac
45
Evin Ademoglu
46
Ayşem Kaya
47
Turkan Nogay
48
Nezaket Eren
49
Melahat Dirican
50
Gul Ozlem Tuncer
51
Mehmet Aykus
52
Yeliz Gunes
53
Sevda Unalli Ozmen
54
Reo Kawano
55
Sehavet Tezcan
56
Ozlem Demirpence
57
Elif Degirmen
Anahtar Kelimeler
biochemical parameters
common reference intervals
multicenter study
regional differences
Turkey
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Ankara Teaching and Research Hospital
Ankara Turkey
Ataturk University, Faculty of Medicine
Erzurum Turkey
Başkent Üniversitesi
Ankara Turkey
Batman Regional State Hospital
Batman Turkey
Bülent Ecevit University
Zonguldak Turkey
Bursa Uludağ Üniversitesi
Bursa Turkey
Dicle University, Faculty of Medicine
Diyarbakir Turkey
Dokuz Eylül Üniversitesi
Izmir Turkey
Gaziantep Üniversitesi
Gaziantep Turkey
Gülhane Eğitim ve Araştırma Hastanesi
Ankara Turkey
Hacettepe Üniversitesi
Ankara Turkey
Invitrolab Laboratory
Elazig Turkey
Istanbul Üniversitesi
Istanbul Turkey
Karadeniz Technical University
Trabzon Turkey
Kars State Hospital
Kars Turkey
Kecioren Teaching and Research Hospital
Ankara Turkey
Luleburgaz State Hospital
Kirklareli Turkey
Manisa Celâl Bayar Üniversitesi
Manisa Turkey
Medicalpark Hospital
Antalya Turkey
Mersin Üniversitesi Tip Fakültesi
Mersin Turkey
Necmettin Erbakan Üniversitesi
Meram Turkey
Ondokuz Mayis University, Medical School
Samsun Turkey
Ordu Üniversitesi
Ordu Turkey
Pamukkale Üniversitesi Tip Fakültesi
Denizli Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Sisli Etfal Hospital
Istanbul Turkey
T. C. Sağlık Bakanlığı, Servergazi Devlet Hastanesi
Denizli Turkey
Yamaguchi University Graduate School of Medicine
Ube Japan
Metrikler
39
Atıf
57
Yazar
5
Anahtar Kelime