Scopus
🔓 Açık Erişim YÖKSİS DOI Eşleşti
SJR Q3
Cytotoxic, anti-proliferative and apoptotic effects of noscapine on human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines
Bratislava Medical Journal · Ocak 2020
YÖKSİS Kayıtları
Cytotoxic, anti-proliferative and apoptotic effects of noscapine on human estrogen receptor positive (MCF-7) and negative (MDA-MB-231) breast cancer cell lines
Bratislava Medical Journal-Bratislavske Lekarske Listy · 2020 SCI-Expanded
Prof. Dr. BAHADIR ÖZTÜRK →
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The effect of acute swimming exercise on plasma leptin in rats
2012 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. AHMET UZUN →
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Prof. Dr. AHMET UZUN →
Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
2011 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. ESMA MENEVŞE →
Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism the role of zinc
2014 ISSN: 0006-9248 SCI-Expanded
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Effect of ankaferd blood stopper on hemostasis and histopathological score in experimental liver injury
2010 ISSN: 0006-9248 SCI-Expanded
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Histological effects of zinc and melatonin on rat testes
2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
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2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Selenium supplementation prevents lipid peroxidation caused by arduous exercise in rat brain tissue
2011 ISSN: 0006-9248 SCI-Expanded 6 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The effect of acute swimming exercise on plasma melatonin levels in rats
2012 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The effect of acute swimming exercise on plasma leptin in rats
2012 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
Protective effect of melatonin on lipid peroxidation in various tissues of diabetic rats subjected to an acute swimming exercise
2012 ISSN: 0006-9248 SCI-Expanded 2 atıf
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The effect of selenium supplementation on elements distribution in liver of rats subject to strenuous swimming
2013 ISSN: 0006-9248 SCI-Expanded
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2013 ISSN: 0006-9248 SCI-Expanded 1 atıf
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Lipid peroxidation in kidney and testis tissues in experimental hypothyroidism the role of zinc
2014 ISSN: 0006-9248 SCI-Expanded 1 atıf
Prof. Dr. RASİM MOĞULKOÇ →
The comparison of the effects of hepatic regeneration after partial hepatectomy silybum marinaum propofol N acetylcysteine and vitamin E on liver
2012 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. SERDAR YORMAZ →
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2015 ISSN: 0006-9248 SCI-Expanded 1 atıf
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2011 ISSN: 0006-9248 SCI-Expanded 6 atıf
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Effect of boron supplementation on plasma element distribution in ovariectomized rats subjected to acute swimming exercise
2011 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. ABDULKERİM KASIM BALTACI →
Histological effects of zinc and melatonin on rat testes
2011 ISSN: 0006-9248 SCI-Expanded 2 atıf
Prof. Dr. ABDULKERİM KASIM BALTACI →
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2012 ISSN: 0006-9248 SCI-Expanded
Prof. Dr. İLHAN ÇİFTCİ →
Makale Bilgileri
ISSN00069248
Yayın TarihiOcak 2020
Cilt / Sayfa121 · 43-50
Scopus ID2-s2.0-85077941497
Erişim🔓 Açık Erişim
Özet
AIM: Noscapine, a naturally occurring alkaloid obtained from opium poppy, is a microtubule-targeting agent. This study is aimed to investigate the effects of noscapine on human breast cancer cell lines by comparing them with those of tamoxifen and docetaxel. METHODS: MCF-7 and MDA MB-23 cell lines were used to observe the effects of docetaxel, tamoxifen, and noscapine on cell proliferation. For each drug, cell blocks were prepared from cultured cells treated with IC50 dose of each drug and these were examined histologically. The expressions of Ki-67, Bcl-2, BAX, and cyclin-D1 were assessed immunohistochemically. RESULTS: Although noscapine showed cytotoxic effects on both cell lines in a time and dose dependent manner, MDA-MB-231 cells were more susceptible to its effects. Noscapine inhibited MCF-7 and MDAMB-231 cells proliferation in vitro with IC50 value of 29 μM and 69 μM, respectively, which was comparable with IC50 of tamoxifen (40 μM and 50 μM) and docetaxel (43 nM and 32 nM). Noscapine showed antiproliferative effects by decreasing Ki-67, cyclin-D1 and apoptotic effects by increasing BAX/Bcl-2 ratio in both breast cancer cells. Its effect was comparable with tamoxifen and docetaxel. CONCLUSION: Noscapine may be a good chemotherapeutic agent for the treatment of breast cancer, especially in estrogen receptor-negative breast cancer (Tab. 2, Fig. 7, Ref. 40). Text in PDF www.elis.sk.
Yazarlar (5)
1
Cengiz Kocak
ORCID: 0000-0003-3819-6822
2
Fatma Emel Kocak
ORCID: 0000-0001-5549-3883
3
Bahadır Öztürk
4
G. Tekin
5
Hüsamettin Vatansev
Anahtar Kelimeler
Breast neoplasms
Docetaxel
Immunohistochemistry
MCF-7 cells
Noscapine
Tamoxifen
Kurumlar
Kütahya Sağlık Bilimleri Üniversitesi
Kutahya Turkey
SelcGBR University
Konya Turkey
Usak University
Usak Turkey
Scimago Dergi (ISSN Eşleşmesi)
Bratislava Medical Journal
Q3
SJR Skoru0,458
H-Index42
YayıncıSpringer International Publishing
ÜlkeSlovakia
Medicine (miscellaneous) (Q3)
Metrikler
16
Atıf
5
Yazar
6
Anahtar Kelime