Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Effect of static magnetic field with quercetin and hesperetin on MCF-7 and MDA MB-231 breast cancer cells
Turkish Journal of Biochemistry · Aralık 2020
YÖKSİS Kayıtları
Effect of static magnetic field with quercetin and hesperetin on MCF-7 and MDA MB-231 breast cancer cells
Turkish Journal of Biochemistry-Turk Biyokimya Dergisi · 2020 SCI-Expanded
PROFESÖR BAHADIR ÖZTÜRK →
Makale Bilgileri
DergiTurkish Journal of Biochemistry
Yayın TarihiAralık 2020
Cilt / Sayfa45 · 833-841
Scopus ID2-s2.0-85098997024
Erişim🔓 Açık Erişim
Özet
Objectives: Static magnetic field (SMF) was previously in practice for the therapy of some diseases and it has been thought that it may be a reliable supportive technique. The aim of this study was to find out the synergistic effect of SMF administration with flavonoids in terms of apoptosis on breast cancer cell lines. Material and methods: The effects of flavonoids on the proliferation of breast cancer cell lines were observed by MTT cell viability test. The cells were treated with SMF + hesperetin and SMF + quercetin. Apoptosis rates and Bax, Bcl-2 protein levels were detected by flow cytometer and Western Blot, respectively. Results: Cell lines were treated with quercetin and quercetin + SMF, substantial amount of cells [3.96, 4.86, 11.40% for MCF-7 and MDA MB-231 cell lines, respectively (p<0.001)] were mainly in the apoptotic phase. The apoptosis rates of hesperetin and hesperetin + SMF were 2.53, 6.06, 10.10% (p<0.001) for MCF-7 and MDA MB- 231 cell lines, respectively. Bax:Bcl-2 ratios were significantly increased after flavonoids + SMF exposure (2.7 vs. 1.6 fold (p<0.0001) in hesperetin + SMF group and 1.8 vs. 1.3-fold (p<0.0001) in quercetin + SMF group for MCF-7 and MDA MB-231 cell lines, respectively. Conclusions: SMF might support the anti-cancer properties of flavonoids, on breast cancer cells via mitochondriarelated apoptosis pathway.
Yazarlar (2)
1
Gulsum Abusoglu
2
Bahadır Öztürk
Anahtar Kelimeler
Apoptosis
Flavonoid
MCF-7
MDA MB-231
Static magnetic fields
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
3
Atıf
2
Yazar
5
Anahtar Kelime