Scopus
🔓 Açık Erişim YÖKSİS Eşleşti
Whole genome sequence and diversity in multigene families of Babesia ovis
Frontiers in Cellular and Infection Microbiology · Ocak 2023
YÖKSİS Kayıtları
Whole genome sequence and diversity in multigene families of Babesia ovis
Frontiers in Cellular and Infection Microbiology · 2023 SCI-Expanded
DOÇENT ONUR CEYLAN →
Whole genome sequence and diversity in multigene families of Babesia ovis
Frontiers in Cellular and Infection Microbiology · 2023 SCI-Expanded
PROFESÖR FERDA SEVİNÇ →
Makale Bilgileri
DergiFrontiers in Cellular and Infection Microbiology
Yayın TarihiOcak 2023
Cilt / Sayfa13
Scopus ID2-s2.0-85168291683
Erişim🔓 Açık Erişim
Özet
Ovine babesiosis, caused by Babesia ovis, is an acute, lethal, and endemic disease worldwide and causes a huge economic loss to animal industry. Pathogen genome sequences can be utilized for selecting diagnostic markers, drug targets, and antigens for vaccine development; however, those for B. ovis have not been available so far. In this study, we obtained a draft genome sequence for B. ovis isolated from an infected sheep in Turkey. The genome size was 7.81 Mbp with 3,419 protein-coding genes. It consisted of 41 contigs, and the N50 was 526 Kbp. There were 259 orthologs identified among eight Babesia spp., Plasmodium falciparum, and Toxoplasma gondii. A phylogeny was estimated on the basis of the orthologs, which showed B. ovis to be closest to B. bovis. There were 43 ves genes identified using hmm model as well. They formed a discriminating cluster to other ves multigene family of Babesia spp. but showed certain similarities to those of B. bovis, B. caballi, and Babesia sp. Xinjiang, which is consistent with the phylogeny. Comparative genomics among B. ovis and B. bovis elucidated uniquely evolved genes in these species, which may account for the adaptation.
Yazarlar (4)
1
Junya Yamagishi
2
Onur Ceylan
3
Xuenan Xuan
4
Ferda Sevinc
Anahtar Kelimeler
apicomplexa
Babesia ovis
comparative genomics
multigene families
ovine babesiosis
Kurumlar
Hokkaido University
Sapporo Japan
Obihiro University of Agriculture and Veterinary Medicine
Obihiro Japan
Selçuk Üniversitesi
Selçuklu Turkey