Scopus
YÖKSİS Eşleşti
Evaluation of liver parenchyma with shear wave elastography in patients with rheumatoid arthritis receiving disease-modifying antirheumatic drug therapy
Journal of Clinical Ultrasound · Ocak 2024
YÖKSİS Kayıtları
Evaluation of Liver Parenchma with Shear Wave Elastograhy in Patients with Rheumotoid Arhritis Receiving Disease-Modifying Antirheumatic Drug Therapy
Journal of Clinical Ultrasound · 2025 SCI-Expanded
PROFESÖR SEMA YILMAZ →
Evaluation of liver parenchyma with shear wave elastography in patients with rheumatoid arthritis receiving disease-modifying antirheumatic drug therapy
J Clin Ultrasound · 2024 SCI-Expanded
PROFESÖR MEHMET SEDAT DURMAZ →
Evaluation of liver parenchyma with shear wave elastography in patients with rheumatoid arthritis receiving disease‐modifying antirheumatic drug therapy
Journal of Clinical Ultrasound · 2025 SCI-Expanded
PROFESÖR MEHMET ÖZTÜRK →
Evaluation of Liver Parenchma with Shear Wave Elastograhy in Patients with Rheumotoid Arhritis Receiving Disease-Modifying Antirheumatic Drug Therapy
Journal of Clinical Ultrasound · 2025 SCI-Expanded
DOÇENT HALİL ÖZER →
Makale Bilgileri
DergiJournal of Clinical Ultrasound
Yayın TarihiOcak 2024
Scopus ID2-s2.0-85204603303
Özet
Background: Methotrexate (MTX) and leflunomide (LEF) play fundamental roles in rheumatoid arthritis (RA) treatment and require proper monitoring of side effects. Concerns about MTX/LEF-related liver fibrosis (LF) in patients with RA remain unclear. This study investigated liver stiffness using two-dimensional shear wave elastography (2D-SWE) in RA patients undergoing disease-modifying antirheumatic drug (DMARD) therapy. Moreover, 2D-SWE was employed to evaluate the correlations between liver stiffness, cumulative MTX and LEF doses and risk factors for substantial LF. Methods: We recruited 222 participants from the Department of Rheumatology. The participants were divided into healthy controls (n = 78) and patients with RA (n = 144). Pearson's correlation analysis was performed to assess the correlations between liver stiffness and the cumulative dose of MTX/LEF and other clinical and laboratory variables. Results: The mean elasticity modulus was 4.79 ± 0.92 kPa, excluding the presence of significant fibrosis. Mean 2D-SWE values were significantly lower in healthy controls than in RA treated with MTX and LEF. The cut-off ≥3.8 kPa 2D-SWE values with the sensitivity of 86.1%, specifity of 83.3%. 2D-SWE values were not significantly different across the strata of the cumulative MTX subgroups. Conclusions: MTX and LEF increase liver stiffness but may be considered low risk for the development of LF.
Yazarlar (7)
1
Dilek Tezcan
ORCID: 0000-0002-8295-9770
2
Halil Özer
ORCID: 0000-0003-1141-1094
3
Ömer Faruk Topaloglu
4
Selda Hakbilen
ORCID: 0000-0002-6417-7310
5
Mehmet Sedat Durmaz
ORCID: 0000-0002-1340-2477
6
Sema Yılmaz
ORCID: 0000-0003-4277-3880
7
Mehmet Ozturk
Anahtar Kelimeler
leflunomide
liver fibrosis
liver stiffness measurement
methotrexate
rheumatoid arthritis
shear wave elastography
Kurumlar
Selçuk Tip Fakültesi
Konya Turkey
University of Health Sciences
Istanbul Turkey