Scopus
YÖKSİS Eşleşti
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics and Gynecology and Reproductive Biology · Eylül 2014
YÖKSİS Kayıtları
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2014 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2014 SSCI
PROFESÖR ÇETİN ÇELİK →
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2014 SCI
PROFESÖR ALİ ÜNLÜ →
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2014 SSCI
PROFESÖR AYBİKE PEKİN →
Metastin levels in relation with hormonal and metabolic profile in patients with polycystic ovary syndrome
European Journal of Obstetrics & Gynecology and Reproductive Biology · 2014 SSCI
PROFESÖR SETENAY ARZU YILMAZ →
Makale Bilgileri
DergiEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Yayın TarihiEylül 2014
Cilt / Sayfa180 · 56-60
Scopus ID2-s2.0-84922382570
Özet
Objective: The aim of the present study was to evaluate serum concentrations of metastin in relation with hormonal and metabolic profile in patients with and without polycystic ovary syndrome (PCOS). Study design: The study was a clinical study. Eighty-three women with PCOS and 66 body mass index (BMI) matched controls were divided into two groups, based on BMI: overweight and obese (BMI ≥ 25 kg/ m2) and normal weight. (BMI < 25 kg/m2) Hirsutism scores, hormonal and metabolic profile as well as metastin levels were evaluated in each subject. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 AM, after an overnight fast. Circulating levels of LH, FSH, PRL, TSH, T, fT, DHEAS, 17-OH-P, sex hormone-binding globulin (SHBG), insulin, glucose, lipid profile and metastin were measured. Results: Metastin levels were significantly higher in the PCOS group compared to controls (2.02 ng/ml versus 1.16 ng/ml, p < 0.001). Metastin levels correlated significantly positively with luteinizing hormone (LH), total testosterone (T), dehydroepiandrosteronesulphate (DHEA-SO4) levels, modified Ferriman- Gallwey (mFG) scores and free androgen index (FAI); however, correlated negatively with sex hormone binding globulin (SHBG) levels (p < 0.05). When overweight or obese (BMI ≥ 25 kg/m2) and normal weight (BMI < 25 kg/m2) women with PCOS were compared to body mass index (BMI) matched controls, higher metastin levels were also found in PCOS groups (1.94 ng/ml versus 1.18 ng/ml, and 2.06 ng/ml versus 1.08 ng/ml, p < 0.05, respectively). Conclusions: These findings suggest that metastin levels were higher in women with PCOS as compared to controls regardless of BMI. Furthermore, metastin levels can be used as a specific marker for androgenic profile and this marker might play a role in the pathogenesis of PCOS.
Yazarlar (7)
1
Setenay Arzu Yilmaz
2
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
3
Aybike Pekin
4
F. N. Incesu
5
N. U. Doğan
6
Çetin Çelik
ORCID: 0000-0001-6165-5092
7
Ali Ünlü
ORCID: 0000-0002-9991-3939
Anahtar Kelimeler
Insulin resistance
Kisspeptin
Metastin
PCOS
Kurumlar
Akdeniz Üniversitesi
Antalya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
32
Atıf
7
Yazar
4
Anahtar Kelime