Scopus
YÖKSİS Eşleşti
The impact of body mass index on radiotherapy technique in patients with early-stage endometrial cancer a single-center dosimetric study
International Journal of Gynecological Cancer · Kasım 2014
YÖKSİS Kayıtları
The Impact of Body Mass Index on Radiotherapy Technique in Patients With Early Stage Endometrial Cancer
International Journal of Gynecological Cancer · 2014 SCI-Expanded
PROFESÖR ÇETİN ÇELİK →
Makale Bilgileri
DergiInternational Journal of Gynecological Cancer
Yayın TarihiKasım 2014
Cilt / Sayfa24 · 1607-1615
Scopus ID2-s2.0-84925940861
Özet
Objective: We aimed to evaluate the impact of body mass index on radiotherapy (RT) technique in patients with early-stage endometrial cancer. Materials and Methods: Twenty-seven consecutive patients were included in the study and divided into 3 groups with respect to their body mass index (normal weight, 18.5-24.9 kg/m2; overweight, 25-29.9 kg/m2; obese, 30-39.9 kg/m2). Treatment plans using field-in-field (FIF) and 3-dimesional conformal RT (3D-CRT) were compared for the doses in the planning target volume (PTV), organs-at-risk (OAR) volumes, dose homogeneity index, and monitor unit counts required for the treatment. Results: The FIF technique was superior to 3D-CRT with respect to the maximum and mean doses received by OAR and dose homogeneity index values. The subgroup analyses revealed that the maximum dose received by the right femur and the mean doses received by the rectum and bladder were significantly reduced only in obese patients (Ps = 0.021, 0.008, and 0.008, respectively). The FIF technique significantly reduced the PTV volumes irradiated with greater than 105% of the prescribed dose (P < 0.001). The volumes of bowel and bone marrow receiving more than the prescribed dose of 30 Gy were significantly reduced only in obese patients (Ps = 0.025 and 0.043, respectively). The volumes of bladder, bowel, and bone marrow receiving more than the prescribed dose of 45 Gy were significantly reduced in only obese patients (Ps = 0.011, 0.011, and 0.008, respectively). Conclusions: Considering the lower maximum doses in OAR and PTV, we demonstrate the FIF technique to be more advantageous than 3D-CRT during adjuvant RT for early-stage endometrial cancer patients. This advantage is more prominent in obese patients. Therefore, FIF technique represents an effective pelvic RT treatment option for obese patients in clinics that do not have access to or prefer an alternative to intensity-modulated RT.
Yazarlar (4)
1
Güler Yavaş
2
Çaǧdaş Yavaş
3
Özlem Seçilmiş Kerimoğlu
ORCID: 0000-0003-2208-8712
4
Çetin Çelik
ORCID: 0000-0001-6165-5092
Anahtar Kelimeler
Body mass index
Dose-volume histograms
Endometrial cancer
Obesity
Radiotherapy
Kurumlar
Konya Training and Research Hospital
United States
Selçuk Tip Fakültesi
Konya Turkey
Selçuk Üniversitesi
Selçuklu Turkey
Metrikler
7
Atıf
4
Yazar
5
Anahtar Kelime